57524-53-5

Basic information

• Product Name: Ethanol,2-[(4-methoxy-2-nitrophenyl)amino]-
• Synonyms: 2-[(2-Nitro-4-methoxyphenyl)amino]ethanol;4-Methoxy-N-(b-hydroxyethyl)-o-nitroaniline
• CAS NO: 57524-53-5
• Molecular Formula: C₉H₁₂N₂O₄
• Molecular Weight: 212.2026
• Mol File: 57524-53-5.mol
• Article Data: 2

Chemical Properties

• Melting Point: 90-92 °C
• Boiling Point: 424.5°Cat760mmHg
• Flash Point: 210.5°C
• Appearance: /
• Density: 1.336g/cm³
• Vapor Pressure: 5.79E-08mmHg at 25°C
• Refractive Index: 1.612
• PKA: 14.61±0.10(Predicted)
• CAS DataBase Reference: Ethanol,2-[(4-methoxy-2-nitrophenyl)amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanol,2-[(4-methoxy-2-nitrophenyl)amino]-(57524-53-5)
• EPA Substance Registry System: Ethanol,2-[(4-methoxy-2-nitrophenyl)amino]-(57524-53-5)

Safety Data

• Hazardous Substances Data: 57524-53-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H12N2O4/c1-15-7-2-3-8(10-4-5-12)9(6-7)11(13)14/h2-3,6,10,12H,4-5H2,1H3

Upstream product

• 89-39-4 1,4-dimethoxy-2-nitrobenzene 
• 141-43-5 ethanolamine 

Downstream Products

• 65235-31-6 4-[(2'-hydroxyethyl)amino]-3-nitrophenol 

Relevant articles and documents

Synthesis method of 3-nitro-4-hydroxyethylaminophenol

The invention relates to a synthesis method of 3-nitro-4-hydroxyethylaminophenol. The method comprises the following steps: reacting a compound shown as a formula I with ethanolamine under a heating condition to obtain a compound shown as formula II; and (2) heating the compound II obtained in the step (1) and hydrobromic acid to a reflux condition, carrying out demethylation reaction to obtain acompound 3-nitro-4-hydroxyethylaminophenol hydrobromide, and carrying out reaction on the compound 3-nitro-4-hydroxyethylaminophenol hydrobromide and concentrated ammonia water to obtain a compound shown as formula III, i.e. a target product. The invention provides a brand-new reaction route, cheap and easily available 4-dimethoxy-2-nitrobenzene and ethanolamine are used as the main raw materials,the whole preparation process is simple, easy to operate and free of high toxicity and high risk, the yield of the obtained product is high, and industrial production is easy to realize; and the rawmaterials ethanolamine and hydrobromic acid in the reaction process can both be recycled, thereby reducing three wastes and saving the cost.