57538-02-0

Basic information

• Product Name: 4-(4-trifluoromethoxybenzamido)cyclohexanone
• Synonyms: 4-(4-trifluoromethoxybenzamido)cyclohexanone
• CAS NO: 57538-02-0
• Molecular Weight: 301.265
• Mol File: 57538-02-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(4-trifluoromethoxybenzamido)cyclohexanone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-trifluoromethoxybenzamido)cyclohexanone(57538-02-0)
• EPA Substance Registry System: 4-(4-trifluoromethoxybenzamido)cyclohexanone(57538-02-0)

Safety Data

• Hazardous Substances Data: 57538-02-0(Hazardous Substances Data)

Upstream product

• 65796-00-1 1-(chloromethyl)-4-(trifluoromethoxy)benzene 
• 6850-65-3 p-hydroxycyclohexylamine 
• 57537-98-1 4-(4-trifluoromethoxybenzamido)cyclohexanol 

Relevant articles and documents

4-[-(Alkoxy or polyhaloalkoxy)-benzamido]cyclohexanones

3-R-3-(Ac2 NH)-9-R'-9-(Ac1 NH)-1,5-dioxaspiro[5.5]undecane (I), where R and R' are each hydrogen or lower-alkyl, Ac1 is lower-alkanoyl or 4-Q1 -benzoyl and Ac2 is 4-Q2 -benzoyl where Q1 and Q2 each is lower-alkoxy or polyhalo-lower-alkoxy, are antifertility agents. The compounds are prepared by di-acylating 3-R-9-R'-1,5-dioxaspiro[5.5]undecan-3,9-diamine (II) or mono-acylating 9-(Ac1 NH)-3-R-9-R'-1,5-dioxaspiro[5.5]undecan-3-amine (IV). IV and II are prepared by oxidizing 4-(Ac1 NH)-4-R'-cyclohexanol (VI) to produce 4-(Ac1 NH)-4-R'-cyclohexanone (VII), reacting VII with 2-NO2 -2-R-1,3-propanediol to produce 3-R-3-NO2 -9-(Ac1 NH)-9-R'-1,5-dioxaspiro[5.5]undecane (VIII), reducing VIII to produce the corresponding 3-amine (IV) and hydrolyzing IV to the corresponding 3,9-diamine (II). Methods of preparing VI are shown.