57574-09-1

Basic information

• Product Name: Amineptine
• Synonyms: amineptine;Survector;amineptin;7-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylamino)heptanoic acid;Heptanoic acid, 7-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)aMino]-;ONNOFKFOZAJDHT-UHFFFAOYSA-N
• CAS NO: 57574-09-1
• Molecular Formula: C22H27NO2
• Molecular Weight: 337.46
• EINECS: 260-818-0
• Product Categories: Amines;Aromatics;Intermediates & Fine Chemicals;Neurochemicals;Pharmaceuticals
• Mol File: 57574-09-1.mol
• Article Data: 0

Chemical Properties

• Melting Point: 209 °C
• Boiling Point: 509.9 °C at 760 mmHg
• Flash Point: 262.2 °C
• Appearance: /
• Density: 1.13 g/cm³
• Vapor Pressure: 3.2E-11mmHg at 25°C
• Refractive Index: 1.596
• PKA: 4.75±0.10(Predicted)
• CAS DataBase Reference: Amineptine(CAS DataBase Reference)
• NIST Chemistry Reference: Amineptine(57574-09-1)
• EPA Substance Registry System: Amineptine(57574-09-1)

Safety Data

• Hazardous Substances Data: 57574-09-1(Hazardous Substances Data)

Usage

Description

Amineptine, also known as Survector, is a carbocyclic fatty acid derivative with a unique chemical structure, characterized by a 5-aminoheptanoic acid backbone and a 10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-yl group attached to the nitrogen atom. It is classified as an atypical tricyclic antidepressant, which was never approved in the United States and was withdrawn from the French market in 1999 due to concerns over abuse, dependence, and severe acne.

Uses

Used in Pharmaceutical Industry:
Amineptine is used as an atypical tricyclic antidepressant for the treatment of depression. It selectively inhibits the reuptake of dopamine and, to a lesser extent, norepinephrine, which helps in alleviating the symptoms of depression. However, its use has been limited due to the potential for abuse, dependence, and side effects such as severe acne.
Used in Research and Development:
Amineptine serves as a valuable compound in the field of neuroscience and pharmacology research. Its unique mechanism of action, involving the selective inhibition of dopamine and norepinephrine reuptake, provides insights into the development of new antidepressant drugs with improved safety profiles and reduced side effects.

Therapeutic Function

Central stimulant

Enzyme inhibitor

This synthetic dopamine reuptake inhibitor (FW = 338.47 g/mol; CAS 57574-09-1), also known by the trade names Survector?, Maneon?, Directim?, Neolior?, Provector?, and Viaspera? as well as its IUPAC name, 7-[(10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5-yl)amino]heptanoic acid, significantly reduces the effect of 6-hydroxy-dopamine on brain dopamine, increases striatal homovanillic acid concentrations, and shows cross-tolerance. Despite these amphetamine-like properties, amineptine does not alter brain noradrenaline or acetylcholine concentrations, suggesting amineptine is a new type of antidepressant with a brain biochemical profile differing from that of other drugs used in depressive disorders. Amineptine is also a norepinephrine reuptake inhibitor. This agent is also ineffective in reducing amphetamine withdrawal symptoms or craving. Amineptine failed to secure FDA approval and is not a duly authorized drug in the U.S.

InChI:InChI=1/C22H27NO2/c24-21(25)13-3-1-2-8-16-23-22-19-11-6-4-9-17(19)14-15-18-10-5-7-12-20(18)22/h4-7,9-12,22-23H,1-3,8,13-16H2,(H,24,25)