57637-97-5

Basic information

• Product Name: N-ACETYLAMINOMETHYLPHOSPHONATE
• Synonyms: N-ACETYLAMINOMETHYLPHOSPHONATE;N-AcetylaMinoMethylphosphoric Acid
• CAS NO: 57637-97-5
• Molecular Formula: C₃H₈NO₄P
• Molecular Weight: 153.07
• Product Categories: Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 57637-97-5.mol
• Article Data: 11

Chemical Properties

• Melting Point: 185 °C(Solv: methanol (67-56-1))
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.483g/cm³
• Refractive Index: 1.484
• Storage Temp.: Refrigerator, Under Inert Atmosphere
• Solubility: Methanol (Slightly, Heated), Water (Slightly)
• PKA: 2.25±0.10(Predicted)
• CAS DataBase Reference: N-ACETYLAMINOMETHYLPHOSPHONATE(CAS DataBase Reference)
• NIST Chemistry Reference: N-ACETYLAMINOMETHYLPHOSPHONATE(57637-97-5)
• EPA Substance Registry System: N-ACETYLAMINOMETHYLPHOSPHONATE(57637-97-5)

Safety Data

• Hazardous Substances Data: 57637-97-5(Hazardous Substances Data)

Usage

Description

N-Acetylaminomethylphosphonate, also known as N-Acetylaminomethylphosphonic Acid, is an organic compound with the chemical formula C3H8NO3P. It is a derivative of aminomethylphosphonic acid, where an acetyl group is attached to the nitrogen atom. N-ACETYLAMINOMETHYLPHOSPHONATE has been studied for its potential applications in various fields due to its unique chemical properties.

Uses

Used in Agriculture:
N-Acetylaminomethylphosphonate is used as an inhibitor for ureases, which are enzymes that catalyze the hydrolysis of urea into ammonia and carbon dioxide. By inhibiting ureases, this compound can help reduce the release of ammonia in the soil, which can be harmful to plants and the environment. This application is particularly useful in agriculture to improve the efficiency of urea-based fertilizers and minimize environmental pollution.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, N-Acetylaminomethylphosphonate may have potential applications in the development of new drugs targeting urease-producing bacteria. These bacteria are often associated with various infections and diseases, such as urinary tract infections, kidney stones, and gastric ulcers caused by Helicobacter pylori. By inhibiting ureases, N-Acetylaminomethylphosphonate could be used as a therapeutic agent to treat these conditions.
Used in Chemical Research:
N-Acetylaminomethylphosphonate can also be used as a research tool in the field of chemistry, particularly in the study of enzyme inhibition and the development of new inhibitors. Its unique structure and properties make it an interesting compound for understanding the mechanisms of urease inhibition and for designing new molecules with improved inhibitory effects.

InChI:InChI=1/C3H8NO4P/c1-3(5)4-2-9(6,7)8/h2H2,1H3,(H,4,5)(H2,6,7,8)

Upstream product

• 625-51-4 N-(hydroxymethyl)acetamide 
• 10294-56-1 phosphorous acid 
• 60-35-5 acetamide 
• 50-00-0 formaldehyd 
• 120060-75-5 N-(triphenylmethyl)methanimine 
• 108-24-7 acetic anhydride 
• 115340-30-2 (Acetylamino-methyl)-phosphonic acid monoethyl ester 
• 20495-31-2 (acetylaminomethyl)phosphonic acid diethyl ester 
• 1066-51-9 Aminomethylphosphonic acid 
• 543-24-8 N-acetylglycine 
• 26028-46-6 1,3,5-tri-acetyl-1,3,5-triaza cyclohexane 

Downstream Products

• 1066-51-9 Aminomethylphosphonic acid 
• 129660-96-4 N-acetylglyphosate 

Relevant articles and documents

Method for synthesizing glyphosate

The invention provides a method for synthesizing glyphosate. The method comprises the following steps: firstly, reacting a compound with a structure shown in a formula (I), paraformaldehyde, an organic solvent, water and a catalyst in a mixed gas atmosphere of carbon monoxide and hydrogen to obtain a compound with a structure shown in a formula (II); then, mixing and hydrolyzing the compound withthe structure shown in the formula (II) and concentrated hydrochloric acid to obtain the glyphosate, specifically, the compound with the structure shown in the formula (I) is used as a reaction raw material to prepare the glyphosate, the source of the reaction raw material is wide, and dimethyl phosphite is not needed to be synthesized as a reaction raw material to prepare the compound with the structure shown in the formula (I), but only phosphorous acid or even phosphorus trichloride can be directly used instead; a byproduct acetic acid prepared in the preparation process of the glyphosate can be used for preparing acetamide for recycling; and compared with an existing method for preparing glyphosate, the method has the advantages that the raw material utilization rate is higher, the process route is simplified, the generated waste liquid is less, and the method has good industrial application prospect.

METHOD FOR THE SYNTHESIS OF ALPHA-AMINOALKYLENEPHOSPHONIC ACID

The present invention is related to a new method for the synthesis of alpha-aminoalkylenephosphonic acid or its phosphonate esters comprising the steps of forming a reaction mixture by mixing a P-O-P anhydride moiety comprising compound, having one P-atom at the oxidation state (+111) and the other P-atom at the oxidation state (+111) or (+V), an aminoalkanecarboxylic acid and an acid catalyst, wherein said reaction mixture comprises an equivalent ratio of alpha-aminoalkylene carboxylic acid to P-O-P anhydride moieties of at least 0.2, and recovering the resulting alpha-aminoalkylene phosphonic acid compound or an ester thereof from the reaction mixture.

1-(N-acylamino)alkanephosphonates. Part IV. N-acylation of 1-aminoalkanephosphonic acids

Practical general procedures of N-acylation of 1-aminoalkanephosphonic acids, including N-acetylation, N-benzoylation and N-pivaloylation of the representative aminophosphonic acids are described. Physico-chemical properties of synthesized derivatives are