57646-33-0Relevant articles and documents
Enantiomerization and enantioselective bioaccumulation of metalaxyl in tenebrio molitor larvae
Gao, Yongxin,Wang, Huili,Qin, Fang,Xu, Peng,Lv, Xiaotian,Li, Jianzhong,Guo, Baoyuan
, p. 88 - 94 (2014)
The enantiomerization and enantioselective bioaccumulation of metalaxyl by a single dose of exposure to Tenebrio molitor larvae under laboratory condition were studied by high-performance liquid chromatography tandem mass spectroscopy (HPLC-MS/MS) based on a ChiralcelOD-3R [cellulosetris-tris-(3, 5-dichlorophenyl-carbamate)] column. Exposure of enantiopure R-metalaxyl and S-metalaxyl in Tenebrio molitor larvae exhibited significant enantiomerization, with formation of the R enantiomers from the S enantiomers, and vice versa, which might be attributed to the chiral pesticide catalyzed by a certain enzyme in Tenebrio molitor larvae. Enantiomerization was not observed in wheat bran during the period of 21 d. In addition, bioaccumulation of rac-metalaxyl in Tenebrio molitor larvae was enantioselective with a preferential accumulation of S-metalaxyl. These results showed that enantioselectivity was caused not only by actual degradation and metabolism but also by enantiomerization, which was an important process in the environmental fate and behavior of metalaxyl enantiomers.
Iridium/chiral diphosphine system catalyzed imine asymmetric hydrogenation method
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Paragraph 0060-0069; 0084-0089, (2019/12/25)
The invention discloses a method for catalyzing asymmetric hydrogenation of imines by an iridium/chiral diphosphine system, which comprises the following steps: reacting a chiral diphosphine ligand with a metal iridium precursor to prepare a complex in situ as a catalyst, and carrying out asymmetric hydrogenation on imines to prepare a chiral amine. The ligand is simple to prepare; catalyst dosage, simple operation, continuous operation can be realized, the preparation method is simple in process and suitable for large-scale preparation of chiral amine, the enantiomeric excess value of the product reaches 80% or above, and the preparation method has is excellent in effect when the S/C (2-ethyl-6-methylaniline/catalyst) rate is 500,000 during synthesis of the s-metolachlor intermediate, theyield reaches 95%, the enantioselectivity reaches 91%, and good industrial practicability is achieved.
Method for preparing chiral amine by asymmetric hydrogenation of imine
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Paragraph 0042; 0043; 0061; 0062, (2019/03/26)
The invention discloses a method for preparing chiral amine by asymmetric hydrogenation of imine. Chiral ferrocene phosphine-diformamidine imine reacts with a metal iridium precursor in situ to prepare a complex which is used as a catalyst, and asymmetric