57658-96-5Relevant articles and documents
Discovery of Novel and Potent Stearoyl Coenzyme A Desaturase 1 (SCD1) Inhibitors as Anticancer Agents
Imamura, Keisuke,Tomita, Naoki,Kawakita, Youichi,Ito, Yoshiteru,Ono, Kouji,Nii, Noriyuki,Miyazaki, Tohru,Yonemori, Kazuko,Tawada, Michiko,Sumi, Hiroyuki,Satoh, Yoshihiko,Yamamoto, Yukiko,Miyahisa, Ikuo,Sasaki, Masako,Satomi, Yoshinori,Hirayama, Megumi,Nishigaki, Ryuichi,Maezaki, Hironobu
, p. 3768 - 3779 (2017/06/13)
A lead compound A was identified previously as an stearoyl coenzyme A desaturase (SCD) inhibitor during research on potential treatments for obesity. This compound showed high SCD1 binding affinity, but a poor pharmacokinetic (PK) profile and limited chem
Discovery of potent, selective, orally bioavailable stearoyl-CoA desaturase 1 inhibitors
Liu, Gang,Lynch, John K.,Freeman, Jennifer,Liu, Bo,Xin, Zhili,Zhao, Hongyu,Serby, Michael D.,Kym, Philip R.,Suhar, Tom S.,Smith, Harriet T.,Cao, Ning,Yang, Ruojing,Janis, Rich S.,Krauser, Joel A.,Cepa, Steven P.,Beno, David W. A.,Sham, Hing L.,Collins, Christine A.,Surowy, Teresa K.,Camp, Heidi S.
, p. 3086 - 3100 (2008/02/10)
Stearoyl-CoA desaturase 1 (SCD1) catalyzes the committed step in the biosynthesis of monounsaturated fatty acids from saturated, long-chain fatty acids. Studies with SCD1 knockout mice have established that these animals are lean and protected from leptin
