57664-47-8

Basic information

• Product Name: 2-(p-Methoxy)phenyl-3-benzoylbenzofuran

Upstream product

• 2491-32-9 1-(4-Hydroxyphenyl)-2-phenylethanone 
• 533-58-4 2-Iodophenol 
• 696-62-8 para-iodoanisole 
• 19234-04-9 2-(p-methoxyphenyl)-benzo[b]furan 
• 98-88-4 benzoyl chloride 
• 31766-64-0 1-methoxy-2-[2-(4-methoxyphenyl)ethynyl]benzene 
• 90-02-8 salicylaldehyde 
• 87444-82-4 2-(p-Hydroxy)phenyl-3-phenyl<1>benzopyrylium chloride 
• 57664-48-9 2-(p-Hydroxy)phenyl-3-benzoylbenzofuran 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 760116-82-3 3-Benzoyl-2-[4'-(2-diethylaminoethoxy)phenyl]benzofuran 
• 87444-83-5 2-Phenyl-3-(p-pyrrolidinoethoxybenzoyl)benzofuran 
• 55877-36-6 2-phenyl-3-(4'-hydroxybenzoyl)benzofuran 
• 55877-35-5 2-phenyl-3-(4'-methoxybenzoyl)benzofuran 

Relevant articles and documents

Nickel-Catalyzed Acyl Group Transfer of o-Alkynylphenol Esters Accompanied by C?O Bond Fission for Synthesis of Benzo[b]furan

Herein, we report the nickel-catalyzed cascade C?O bond cleavage/cyclization of ortho-alkynylphenyl ester to construct a 3-acylbenzo[b]furan skeleton. As a result of reaction condition screening, the Ni(0)/IAd (1,3-Di(1-adamantyl)imidazole-2-ylidene) system was found to be optimal for catalytic conversion. Interestingly, the reaction exclusively gives 3-acylbenzo[b]furan instead of a decarbonylated product frequently observed in reactions mediated by acyl-nickel species. The catalyst loadings could be reduced to 5–10 mol %. We demonstrated the synthesis of a variety of functionalized 3-acylbenzofuran derivatives. We conducted stoichiometric study of nickel complexes as well as density functional theory (DFT) calculations to support a possible reaction mechanism.

A Convenient Synthesis of 2-Aryl-3-aroylbenzofurans

The rearrangement of 2-(p-hydroxy)phenyl-3-phenylbenzopyrylium chloride (1), catalysed by H2O2/H2SO4, furnishes 2-(p-hydroxy)phenyl-3-benzoylbenzofuran (2) which is methylated to 3, and then subjected to acid catalysed rearrangement to afford 4.The