57671-12-2

Basic information

• Product Name: Pyrrolidine, 1-[(4-methylphenyl)sulfinyl]-
• CAS NO: 57671-12-2
• Molecular Formula: C11H15NOS
• Molecular Weight: 209.312
• Mol File: 57671-12-2.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Pyrrolidine, 1-[(4-methylphenyl)sulfinyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrrolidine, 1-[(4-methylphenyl)sulfinyl]-(57671-12-2)
• EPA Substance Registry System: Pyrrolidine, 1-[(4-methylphenyl)sulfinyl]-(57671-12-2)

Safety Data

• Hazardous Substances Data: 57671-12-2(Hazardous Substances Data)

Upstream product

• 123-75-1 pyrrolidine 
• 98-59-9 p-toluenesulfonyl chloride 
• 6873-55-8 p-tolylsulfinyl amide 
• 536-57-2 p-toluene sulfinic acid 
• 68388-05-6 O-benzoyl-N-hydroxylpyrrolidine 
• 103-19-5 di(p-tolyl) disulfide 
• 106-45-6 para-thiocresol 
• 672-78-6 methyl p-toluene sulfinate 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 1858-86-2 Ethyl p-toluenesulfinate 

Downstream Products

• 6435-78-5 N-tosylpyrrolidine 
• 5056-07-5 (S)-methyl p-tolyl sulfoxide 
• 64353-47-5 (+)-(S)-N-p-tolylsulfinylpyrrolidine 
• 536-57-2 p-toluene sulfinic acid 
• 151647-54-0 3-phenyl-1-pyrrolidin-1-yl-propane-1-one 
• 123-75-1 pyrrolidine 
• 672-78-6 methyl p-toluene sulfinate 

Relevant articles and documents

Rare-Earth-Catalyzed Transsulfinamidation of Sulfinamides with Amines

A rare-earth-catalyzed transsulfinamidation of primary sulfinamides with alkyl, aryl, and heterocyclic amines for the synthesis of diverse secondary and tertiary sulfinamides has been realized. Unlike transition metal-catalyzed cross-coupling approaches restricted to non-commercially available disubstituted O-benzoyl hydroxylamines, this newly developed protocol is suitable for diverse readily available primary and secondary amines without any modifications. Excellent catalytic activity and selectivity are achieved with Eu(OTf)3 under mild reaction conditions, which extends the applicability of rare-earth catalysis.

Ni/NHC-catalyzed cross-coupling of methyl sulfinates and amines for direct access to sulfinamides

It was reported to develop a simple and convenient method for the Ni/NHC-catalyzed cross-coupling of methyl sulfinates and amines without an acid/base to afford secondary or tertiary sulfinamides in moderate to good yields. The method can provide the desired products with broad substrate scope, good chemoselectivity and good functional group compatibility. The presented approach may enrich the Ni/NHC catalyst system and promote the applications of methyl sulfinates in the organic sulfur chemistry.

Copper-Catalyzed Transsulfinamidation of Sulfinamides as a Key Step in the Preparation of Sulfonamides and Sulfonimidamides

Secondary or tertiary sulfinamides are prepared by copper-catalyzed transsulfinamidation of primary sulfinamides with O-benzoyl hydroxylamines. Subsequent oxidations of the resulting products lead to the corresponding sulfonamides. Treatment of N-aryl sulfinamides with O-benzoyl hydroxylamines under copper catalysis provides N-aryl sulfonimidamides.