57707-11-6Relevant articles and documents
Facile synthesis of 4-substituted 1,2,4,5-tetrahydro-1,4-benzodiazepin-3-ones by reductive cyclization of 2-chloro-N-(2-nitrobenzyl)acetamides
Sasiambarrena, Leandro D.,Barri, Ivan A.,Fraga, Guido G.,Bravo, Rodolfo D.,Ponzinibbio, Agustín
supporting information, p. 264 - 267 (2019/01/04)
A facile and efficient method was developed for the synthesis of 1,2,4,5-tetrahydro-1,4-benzodiazepine-3-ones from 2-chloro-N-(2-nitrobenzyl)acetamides through a reductive cyclization using iron-ammonium chloride in ethanol–water in good yields. This method provides a simple approach to these benzodiazepine-3-ones which are of high value in the field of medicinal chemistry research.
Synthesis of N-methyl imines in the presence of poly(N-vinylpyridine) as a reusable solid base catalyst by a mechanochemical process
Khaligh, Nader Ghaffari,Abbo, Hanna S.,Titinchi, Salam J. J.
, p. 901 - 910 (2017/02/10)
The synthesis of N-methyl imines was performed in the presence of catalytic amounts of poly(4-vinylpyridine) in high yields and rapidly at room temperature by a ball milling process. This new method has some advantages including good yields for relatively unreactive carbonyl compounds and short reaction times as well as being green in terms of avoiding the use of toxic reagents and solvents. The major advantage of this process is that the catalyst can be easily regenerated and reused several times without any significant loss of activity.
Substituent-controlled annuloselectivity and stereoselectivity in the sulfa-Staudinger cycloadditions
Yang, Zhanhui,Chen, Ning,Xu, Jiaxi
, p. 3611 - 3620 (2015/04/22)
In the sulfa-Staudinger cycloadditions of imines and sulfonyl chlorides, the annuloselectivity is mainly controlled by the electronic effect of the α-substituents of sulfonyl chlorides and the nucleophilicity of imines. Sulfonyl chlorides with weakly elec