57724-34-2

Basic information

• Product Name: Propanedioic acid, [1-(3,4-dimethoxyphenyl)-2-nitroethyl]-, diethyl ester
• CAS NO: 57724-34-2
• Molecular Formula: C17H23NO8
• Molecular Weight: 369.372
• Mol File: 57724-34-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Propanedioic acid, [1-(3,4-dimethoxyphenyl)-2-nitroethyl]-, diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Propanedioic acid, [1-(3,4-dimethoxyphenyl)-2-nitroethyl]-, diethyl ester(57724-34-2)
• EPA Substance Registry System: Propanedioic acid, [1-(3,4-dimethoxyphenyl)-2-nitroethyl]-, diethyl ester(57724-34-2)

Safety Data

• Hazardous Substances Data: 57724-34-2(Hazardous Substances Data)

Upstream product

• 4230-93-7 1,2-dimethoxy-4-(2-nitro-vinyl)-benzene 
• 105-53-3 diethyl malonate 

Downstream Products

• 1593957-81-3 diethyl 2-[2-(3,4-dimethoxyphenyl)-2-oxoethylidene]malonate 

Relevant articles and documents

One pot domino reaction accessing γ-nitroesters: Synthesis of GABA derivatives

Michael addition of 1,3-dicarbonyl compounds to nitrostyrenes is efficiently promoted by hydrotalcite [Mg-Al] to afford the respective γ-nitrodicarbonyl adducts. Differently, the addition of Meldrum's acid leads to a direct access of γ-nitroesters through a one pot domino process. GABA derivatives (+/-)-phenibut and (+/-)-baclofen were readily synthesized from the respective nitro adducts.