57744-68-0 Usage
Description
7-bromo-3,4-dihydronaphthalen-1(2H)-one is an organic compound with a molecular structure that features a naphthalene ring system, a bromine atom, and a ketone functional group. It is a type of dihydronaphthalenone derivative, which is known for its potential applications in various chemical and pharmaceutical industries due to its unique chemical properties.
Uses
Used in Pharmaceutical Industry:
7-bromo-3,4-dihydronaphthalen-1(2H)-one is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure allows it to be a key component in the development of new drugs, particularly those targeting specific enzyme systems.
Used in Chemical Synthesis:
In the chemical industry, 7-bromo-3,4-dihydronaphthalen-1(2H)-one serves as a versatile building block for the creation of a wide range of organic compounds. Its reactivity and structural features make it suitable for use in the synthesis of various specialty chemicals, including dyes, pigments, and other complex organic molecules.
Used in Enzyme Inhibition:
7-bromo-3,4-dihydronaphthalen-1(2H)-one is used as a matrix metalloproteinase (MMP) inhibitor, specifically targeting MMP-12 and MMP-13. These enzymes are involved in various physiological processes, and their inhibition can be beneficial in treating conditions related to their overactivity, such as certain types of cancer and inflammatory diseases.
Synthesis Reference(s)
Tetrahedron Letters, 37, p. 2441, 1996 DOI: 10.1016/0040-4039(96)00313-9
Check Digit Verification of cas no
The CAS Registry Mumber 57744-68-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,7,7,4 and 4 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 57744-68:
(7*5)+(6*7)+(5*7)+(4*4)+(3*4)+(2*6)+(1*8)=160
160 % 10 = 0
So 57744-68-0 is a valid CAS Registry Number.
InChI:InChI=1/C8H7ClO2/c9-6-1-2-7-8(5-6)11-4-3-10-7/h1-2,5H,3-4H2
57744-68-0Relevant articles and documents
Preparation method of thiazole derivative
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Paragraph 0022; 0023; 0024, (2018/03/24)
The invention discloses a preparation method of a thiazole derivative which is (4-(7-chlorine-2,3-dihydrobenzo[b][1,4]dioxane-6-yl)thiazole-2-yl)methanol. The method is characterized by taking 4-chlorocatechol as a starting raw material, carrying out cyclization, Friedel-Crafts reaction, cyclization, deacetalization protection and reduction to obtain the target product. The compound is used as animportant medical intermediate.
Formation and synthetic use of oxygen-centred radicals with (diacetoxyiodo)arenes
Togo, Hideo,Muraki, Takahito,Hoshina, Yoichiro,Yamaguchi, Kentaro,Yokoyama, Masataka
, p. 787 - 793 (2007/10/03)
o-Alkyl- or o-aryl-benzenecarboxylic acids and alcohols containing an aromatic ring are treated with a (diacetoxyiodo)arene-iodine system to give the corresponding cyclized products such as phthalide, benzocoumarin and chromane derivatives in moderate to good yields via the corresponding oxygen-centred radicals. For the carboxylic acids, [bis(trifluoroacetoxy)iodo]benzene functions effectively, while (diacetoxyiodo)benzene is effective for the alcohols. Chromane and its derivatives are obtained as iodinated compounds by hypoiodite species derived from (diacetoxyiodo)benzene and iodine. Copyright 1997 by the Royal Society of Chemistry.
HOMOLYTIC AMINATION OF BENZO-1,4-DIOXANE
Zorina, L.N.,Safiev, O.G.,Rakhmankulov, D.L.
, p. 261 - 263 (2007/10/02)
When 5,6-benzo-1,4-dioxane was reacted with N,N-dialkylchloramines in the presence of FeSO4 at 10-20 deg C in a solution of acetic and sulfuric acids, 6-(N,N-dialkylamino)benzo-1,4-dioxanes and 6-chloro- and 6,7-dichlorobenzo-1,4-dioxanes were obtained.Under the conditions used in the study mainly chlorination products were synthesized.Reaction of 5,6-benzo-1,4-dioxane with the system (NH3OH)2SO4-TiCl3 resulted in the formation of 6-aminobenzo-1,4-dioxane.
