57769-48-9

Basic information

• Product Name: methyl N-(tert-butoxycarbonyl)tryptophylglycinate
• CAS NO: 57769-48-9
• Molecular Formula: C₁₉H₂₅N₃O₅
• Molecular Weight: 375.4189
• Mol File: 57769-48-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 619.6°C at 760 mmHg
• Flash Point: 328.5°C
• Density: 1.229g/cm³
• Vapor Pressure: 2.8E-15mmHg at 25°C
• Refractive Index: 1.571
• CAS DataBase Reference: methyl N-(tert-butoxycarbonyl)tryptophylglycinate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl N-(tert-butoxycarbonyl)tryptophylglycinate(57769-48-9)
• EPA Substance Registry System: methyl N-(tert-butoxycarbonyl)tryptophylglycinate(57769-48-9)

Safety Data

• Hazardous Substances Data: 57769-48-9(Hazardous Substances Data)

Upstream product

• 5680-79-5 glycine ethyl ester hydrochloride 
• 141215-69-2 methyl (2S)-2-{[(tert-butoxy)carbonyl]amino}-3-(1H-indol-3-yl)propanoate 
• 13139-14-5 Boc-Trp-OH 
• 3392-11-8 2,5-dioxopyrrolidin-1-yl N-(tert-butoxycarbonyl)-L-tryptophanate 

Relevant articles and documents

Late-stage construction of stapled peptides through Fujiwara-Moritani reaction between tryptophan and olefins

Herein, the first example of a palladium-catalyzed Fujiwara-Moritani reaction for olefination of tryptophan (Trp) residues, free from directing groups, was presented. The developed reaction proceeds efficiently for peptide modification, ligation and pepti

CONTINUOUS, SOLVENT-FREE AND NON-ENZYMATIC PEPTIDE SYNTHESIS BY REACTIVE EXTRUSION

The present disclosure relates to A a continuous, solvent-free and non-enzymatic method for synthesizing a compound of formula (I): Ra-POLYPEP-Rc (I) wherein: POLYPEP is a poly-amino acid compound, Ra and Rc are as specified in the disclosure, which method comprises the steps of: a) feeding an extrusion reactor with (1) a compound of formula (II) Ra-PEPNt-Rg (II) wherein; PEPNt is a mono- or a poly-aminoacid compound, Ra and Rg are as specified in the disclosure, and (2) a compound of formula (III) H-PEPCt-Rc (III) wherein: PEPCt is a mono- or a poly-amino acid compound, and Rc is as defined in the disclosure in the absence of any solvent, so that the compound of formula (II) and the compound of formula (III) react together for generating a compound of formula (I), and b) collecting the compound of formula (I) from the extrusion reactor.