57780-75-3

Basic information

• Product Name: 2-NITRO-5-(PROPYLTHIO)ANILINE
• Synonyms: 2-NITRO-5-(PROPYLTHIO)ANILINE;2-nitro-5-(propylthio)-benzenamin;[2-Nitro-5-(propylthio)phenyl]amine;2-Nitro-5-(propylthio)aniline 99%;benzenamine, 2-nitro-5-(propylthio)-
• CAS NO: 57780-75-3
• Molecular Formula: C₉H₁₂N₂O₂S
• Molecular Weight: 212.27
• Product Categories: Building Blocks;Chemical Synthesis;Organic Building Blocks;Sulfides/Disulfides;Sulfur Compounds
• Mol File: 57780-75-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 71-74 °C(lit.)
• Boiling Point: 380.3 °C at 760 mmHg
• Flash Point: 183.8 °C
• Appearance: /
• Density: 1.25 g/cm³
• Vapor Pressure: 5.52E-06mmHg at 25°C
• Refractive Index: 1.607
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: -0.87±0.25(Predicted)
• CAS DataBase Reference: 2-NITRO-5-(PROPYLTHIO)ANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-NITRO-5-(PROPYLTHIO)ANILINE(57780-75-3)
• EPA Substance Registry System: 2-NITRO-5-(PROPYLTHIO)ANILINE(57780-75-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 57780-75-3(Hazardous Substances Data)

Usage

Description

2-Nitro-5-(propylthio)aniline is a sulfur-containing organic building block, which is a chemical compound with a molecular structure that includes a nitro group and a propylthio group attached to an aniline molecule.

Uses

Used in Pharmaceutical Industry:
2-NITRO-5-(PROPYLTHIO)ANILINE is used as a reagent for the synthesis of analogues of Albendazole (A511610) and Mebendazole (M200500), compounds which have potential antiparasitic activity. This application is significant in the development of new drugs to combat parasitic infections, as these analogues may offer improved efficacy or reduced side effects compared to existing treatments.

InChI:InChI=1/C9H12N2O2S/c1-2-5-14-7-3-4-9(11(12)13)8(10)6-7/h3-4,6H,2,5,10H2,1H3

Upstream product

• 1635-61-6 5-chloro-2-nitroaniline 
• 106-94-5 propyl bromide 
• 107-08-4 1-iodo-propane 
• 5443-33-4 N-(5-chloro-2-nitrophenyl)acetamide 
• 107-03-9 1-thiopropane 
• 108-42-9 3-chloro-aniline 

Downstream Products

• 65671-10-5 1-(3-carbomethoxythioureido)-2-nitro-5-propylthiobenzene 
• 70122-58-6 C₂₂H₂₅N₃O₂S₂ 
• 70122-71-3 C₁₉H₂₀N₄O₄S₂ 
• 70122-69-9 C₂₀H₂₃N₃O₃S₂ 
• 70244-21-2 C₁₉H₂₀ClN₃O₂S₂ 
• 65671-11-6 1-(3-carbomethoxythioureido)-2-amino-5-propylthiobenzene 
• 70122-54-2 C₂₀H₂₂ClN₃O₂S₂ 
• 70244-20-1 C₂₀H₂₃N₃O₂S₂ 
• 67170-01-8 2-Amino-5-propylthio-propionanilid 
• 66608-52-4 4-(propylthio)-1,2-phenylenediamine 

Relevant articles and documents

Novel preparation method of albendazole

The invention provides a novel preparation method of albendazole. According to the invention, a novel synthetic route of albendazole is provided, wherein 2-nitro-5-chloroaniline is used as a startingmaterial and is subjected to reactions of substitution, condensation, reduction and cyclization to obtain high-purity albendazole. The method is characterized in that: the 2-nitro-5-chloroaniline is subjected to substituted reaction, and is subjected to condensation reaction with halogenated n-propane to obtain 2-nitro-5-albendazole aniline, which avoids the use of propanethiol with a high price and a stimulating odor. The use of a high-risk hydrogenation reduction process is avoided, a vulcanization alkali reduction process which is cheap and easily available in raw materials is used, a set of non-toxic treatment schemes for reducing layered waste water are provided, and meanwhile, secondary sodium thiosulfate can be obtained and the waste is turned into wealth. According to the method, the yield is high, the safety risk is low, the industrial production is facilitated, the content of the prepared albendazole is high, the content of single impurities is small, and the latest standardssuch as the US Pharmacopeia and the European Pharmacopoeia are met.

Preparation of N-methoxycarbonyl-N'-[2-nitro-4(5)-propyl-thiophenyl]thiourea as prodrugs of albendazole

N-methoxycarbonyl-N'-(2-nitro-4-propylthiophenyl)thiourea and N-methoxycarbonyl-N'-(2-nitro-5-propylthiophenyl)thiourea, prodrugs of albendazole, have been synthesized. The biotransformation in rats, after oral administration of these prodrugs to albendazole and albendazole sulphoxide, is described.