577971-19-8 Usage
Description
2-(2'-Di-tert-butylphosphine)biphenylpalladium(II) acetate is a novel, airand moisture-and thermally stable catalyst that plays a significant role in various chemical reactions and applications, particularly in the field of pharmaceuticals and organic synthesis.
Uses
Used in Pharmaceutical Industry:
2-(2'-Di-tert-butylphosphine)biphenylpalladium(II) acetate is used as a precatalyst for the Buchwald-Hartwig amination reaction, which is a crucial process in the synthesis of various pharmaceutical compounds, including anticancer LPA2 antagonists. This reaction allows for the formation of carbon-nitrogen bonds, which are essential in the development of complex molecular structures with potential therapeutic applications.
Used in Organic Synthesis:
2-(2'-Di-tert-butylphosphine)biphenylpalladium(II) acetate is used as a pre-catalyst for the amination of aryl halides, specifically aryl chlorides. This application is significant in organic synthesis, as it enables the formation of new compounds with potential applications in various industries, such as the development of new materials, dyes, and pharmaceuticals.
Used in the Synthesis of N-methyl-6-heterocyclic-1-oxoisoindoline Derivatives:
2-(2'-Di-tert-butylphosphine)biphenylpalladium(II) acetate is utilized in the preparation of N-methyl-6-heterocyclic-1-oxoisoindoline derivatives via the Buchwald-Hartwig amination reaction of N-methyl-6-bromoisoindoline-1-one with different amines under microwave conditions. These derivatives have potential applications in various fields, including pharmaceuticals and materials science.
Check Digit Verification of cas no
The CAS Registry Mumber 577971-19-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,7,7,9,7 and 1 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 577971-19:
(8*5)+(7*7)+(6*7)+(5*9)+(4*7)+(3*1)+(2*1)+(1*9)=218
218 % 10 = 8
So 577971-19-8 is a valid CAS Registry Number.
InChI:InChI=1S/C20H26P.C2H4O2.Pd/c1-19(2,3)21(20(4,5)6)18-15-11-10-14-17(18)16-12-8-7-9-13-16;1-2(3)4;/h7-12,14-15H,1-6H3;1H3,(H,3,4);/q;;+1/p-1