578021-55-3

Basic information

• Product Name: 1,4-Piperidinedicarboxylic acid, 4-ethyl-, 1-(1,1-dimethylethyl) 4-methyl ester
• Synonyms: 1,4-Piperidinedicarboxylic acid, 4-ethyl-, 1-(1,1-dimethylethyl) 4-methyl ester;Methyl N-Boc-4-ethylpiperidine-4-carboxylate;4-Piperidinedicarboxylic acid, 4-ethyl-, 1-(1,1-dimethylethyl) 4-methyl ester;4-Piperidinedicarboxylic acid
• CAS NO: 578021-55-3
• Molecular Formula: C14H25NO4
• Molecular Weight: 271.35
• Mol File: 578021-55-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 329.872 °C at 760 mmHg
• Flash Point: 153.302 °C
• Appearance: /
• Density: 1.05 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.549
• Storage Temp.: 2-8°C
• PKA: -2.26±0.40(Predicted)
• CAS DataBase Reference: 1,4-Piperidinedicarboxylic acid, 4-ethyl-, 1-(1,1-dimethylethyl) 4-methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-Piperidinedicarboxylic acid, 4-ethyl-, 1-(1,1-dimethylethyl) 4-methyl ester(578021-55-3)
• EPA Substance Registry System: 1,4-Piperidinedicarboxylic acid, 4-ethyl-, 1-(1,1-dimethylethyl) 4-methyl ester(578021-55-3)

Safety Data

• Hazardous Substances Data: 578021-55-3(Hazardous Substances Data)

Usage

General Description

1,4-Piperidinedicarboxylic acid, 4-ethyl-, 1-(1,1-dimethylethyl) 4-methyl ester is a chemical compound that belongs to the class of piperidine carboxylic acid esters. It is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. 1,4-Piperidinedicarboxylic acid, 4-ethyl-, 1-(1,1-dimethylethyl) 4-methyl ester is known for its potential therapeutic applications, including its role as a glutamate receptor antagonist, which may have implications in the treatment of neurological disorders. Additionally, it has been studied for its anti-inflammatory and analgesic properties, making it a subject of interest in the development of new medications. However, further research is needed to fully understand the potential applications and effects of this compound.

InChI:InChI=1/C7H11NO4/c9-6(10)5-1-3-8(4-2-5)7(11)12/h5H,1-4H2,(H,9,10)(H,11,12)

Upstream product

• 124443-68-1 1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate 
• 75-03-6 ethyl iodide 
• 74-96-4 ethyl bromide 

Downstream Products

• 741687-07-0 tert-butyl 4-amino-4-ethylpiperidine-1-carboxylate 
• 188792-67-8 1-(tert-butoxycarbonyl)-4-ethylpiperidine-4-carboxylic acid 
• 885523-41-1 1-boc-4-ethyl-4-formylpiperidine 

Relevant articles and documents

QUINUCLIDINONE ANALOGUES AS ANTICANCER AGENTS

The disclosure includes compounds of Formula (I) and Formula(A) wherein R1, R2, R3, m, n, k, and L are defined herein. Also disclosed are methods for treating a neoplastic disease, autoimmune disease, or an inflammatory disorder with these compounds.

Muscarinic M3 receptor antagonists with (2R)-2-[(1R)-3,3-Difluorocyclopentyl]-2-hydroxyphenylacetamide Structures. Part 2

Optimization of the amine part of our original muscarinic M3 receptor antagonist 1 was performed to identify M3 receptor antagonists that are superior to 1. Compounds carrying a variety of diamine moieties without hydrophobic substituent on the nitrogen atom were screened against the binding affinity for the M3 receptor and the selectivity for M3 over the M1 and M2 receptors. This process led to a 4-aminopiperidinamide (2l) with a Ki value of 5.1 nM and with a selectivity of the M3 receptor that was 46-fold greater than that of the M2 receptor. Further derivatization of 2l by inserting a spacer group or by incorporating alkyl group(s) into the amine part resulted in the identification of an 4-(aminoethyl)piperidinamide 2l-b with a Ki value of 3.7 nM for the M3 receptor and a selectivity for the M3 receptor that was 170-fold greater than that of the M2 receptor.