57817-83-1

Basic information

• Product Name: N(6),O(2)-Dimethyladenosine
• CAS NO: 57817-83-1
• Molecular Formula: C₁₂H₁₇N₅O₄
• Molecular Weight: 295.2945
• Mol File: 57817-83-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 606.5°Cat760mmHg
• Flash Point: 320.6°C
• Density: 1.68g/cm³
• CAS DataBase Reference: N(6),O(2)-Dimethyladenosine(CAS DataBase Reference)
• NIST Chemistry Reference: N(6),O(2)-Dimethyladenosine(57817-83-1)
• EPA Substance Registry System: N(6),O(2)-Dimethyladenosine(57817-83-1)

Safety Data

• Hazardous Substances Data: 57817-83-1(Hazardous Substances Data)

Upstream product

• 512-56-1 trimethyl phosphite 
• 58-61-7 adenosine 
• 17287-03-5 trimethylsulphonium hydroxide 
• 1899-02-1 trimethylphenylammonium hydroxide 
• 74230-06-1 trimethylselenonium hydroxyde 
• 2140-79-6 2'-O-methyl adenosine 

Downstream Products

• 2140-79-6 2'-O-methyl adenosine 

Relevant articles and documents

Selective 2'-O-Methylation of Pyrimidine-Ribonucleosides by Trimethylsulfonium Hydroxide in the Presence of Mg2+ and Ca2+ Ions

Reactions of various ribonucleosides with trimethylsulfonium hydroxide were investigated in the presence of Mg2+ and Ca2+ ions.The 2'-OH groups of pyrimidine-ribonucleosides were methylated selectively.

The Methylation of Ribonucleosides by Trimethyl Phosphate or Dimethyl Sulfate in the Presence of Boric Acid

Uridine, inosine, adenosine, and thymidine were methylated selectively at the base moieties by the use of trimethyl phosphate or dimethyl sulfate in the presence of boric acid.A suppressing effect of boric acid on the methylation of the ribose-hydroxyl groups was discussed briefly.

Methylation study of ribonucleosides, deoxyribonucleosides, and 2′-O-methylribonucleosides with trimethylsulphonium hydroxide and trimethylsulphonium iodide. Influence of the 2′-hydroxy-groups on the reactivity of the base moieties of ribonucleosides

Methylations of the naturally occuring ribonucleoside (1), deoxyribonucleoside (2), and 2′-O-methylribonucleoside (3) were carried out using trimethylsulphonium hydroxide (Me3SOH) and trimethylsulphonium iodide (Me3Sl). The base moiety of (2) and (3) are more reactive than the corresponding base moiety of (1). The sites and extent of methylation of (2) are considerably different from those of (1), but are almost identical with those of (3). The reactivities of (1)-(3) are discussed in connection to an intramolecular interaction of the 2′-OH groups with the base moiety of (1). The methylating characteristics of Me 3SOH and Me3Sl are also described. The kinetics indicate an SN2 mechanism for methylation of nucleosides by Me 3S+ ions.