57830-14-5

Basic information

• Product Name: 1(3H)-Isobenzofuranone, 5-phenoxy-
• Synonyms: 1(3H)-Isobenzofuranone, 5-phenoxy-;5-phenoxyisobenzofuran -1(3H)-one;5-Phenoxy-1(3H)-isobenzofuranone;1(3H)-Isobenzofuranone, 5-phenoxy- (Related Reference);5-phenoxy-3H-2-benzofuran-1-one
• CAS NO: 57830-14-5
• Molecular Formula: C₁₄H₁₀O₃
• Molecular Weight: 226.2274
• Mol File: 57830-14-5.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 422.467 °C at 760 mmHg
• Flash Point: 179.748 °C
• Appearance: /
• Density: 1.280
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1(3H)-Isobenzofuranone, 5-phenoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: 1(3H)-Isobenzofuranone, 5-phenoxy-(57830-14-5)
• EPA Substance Registry System: 1(3H)-Isobenzofuranone, 5-phenoxy-(57830-14-5)

Safety Data

• Hazardous Substances Data: 57830-14-5(Hazardous Substances Data)

Usage

General Description

"1(3H)-Isobenzofuranone, 5-phenoxy-" is a compound belonging to the class of chemicals called organic compounds. Organic compounds are primarily made of carbon atoms and can contain other elements such as hydrogen, nitrogen, oxygen, etc. As a chemical, "1(3H)-Isobenzofuranone, 5-phenoxy-" does not have any known practical applications or uses. Essential properties such as the molecular weight, boiling point, melting point, solubility, etc. are not documented for this compound. Owing to a lack of research, potential health effects or hazards associated with this chemical also remain largely unknown.

Upstream product

• 2215-77-2 4-Phenoxybenzoic acid 
• 74-95-3 1,1-dibromomethane 
• 63197-24-0 4-phenoxy-N-methyl phthalimide 
• 201230-82-2 carbon monoxide 
• 6941-75-9 5-Bromoisoindoline-1,3-dione 
• 139-02-6 sodium phenoxide 
• 89-40-7 4-nitrophthalimide 
• 301208-03-7 4-phenoxy-phthalimide 
• 90224-73-0 5-bromo-2-methyl-2,3-dihydro-1H-isoindole-1,3-dione 
• 41663-84-7 4-nitro-N-methyl-phthalimide 
• 108-95-2 phenol 
• 64169-34-2 5-bromophthalide 

Downstream Products

• 1455091-04-9 2-(chloromethyl)-4-phenoxybenzoic acid methyl ester 
• 1421312-35-7 4-hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid 
• 1455087-16-7 4-{[(4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]methyl}tetrahydropyran-4-carboxylic acid 
• 1455091-29-8 4-{[(4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]methyl}tetrahydropyran-4-carboxylic acid methyl ester 
• 1455087-12-3 1-{[(4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]methyl}cyclobutanecarboxylic acid 
• 1455091-26-5 1-{[(4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]methyl}cyclobutanecarboxylic acid methyl ester 
• 1455090-32-0 4-[(1-cyano-4-hydroxy-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]butyric acid 
• 1455094-84-4 4-[(1-cyano-4-hydroxy-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]butyric acid methyl ester 
• 1455094-82-2 4-[(4-hydroxy-1-iodo-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]butyric acid methyl ester 
• 1455094-80-0 4-[(4-hydroxy-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]butyric acid methyl ester 
• 1455094-78-6 4-[(4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]butyric acid methyl ester 
• 1455090-30-8 3-[(1-cyano-4-hydroxy-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylpropionic acid 
• 1455094-75-3 3-[(1-cyano-4-hydroxy-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylpropionic acid ethyl ester 
• 1455094-73-1 3-[(4-hydroxy-1-iodo-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylpropionic acid ethyl ester 

Relevant articles and documents

Synthesis of 5-phenoxyisobenzofuran-1(3H)-one as a key intermedate of the drug roxadustat

In this paper, a novel synthetic route to the key intermediate of the drug Roxadustat, 5-phenoxyisobenzofuran-1(3H)-one, was achieved in two steps in overall 78percent yield by using (3-phenoxyphenyl) methanol as the starting material. The synthetic route has the advantages of fewer steps, good regioselectivity, low catalyst consumption, high yield and lower raw material costs which are beneficial to realize industrial production.

Preparation method of isoquinoline derivative

Disclosed is a preparation method of an isoquinoline derivative. A preparation method of a compound represented by a general formula II, i.e., 4-hydroxy-1-methyl-7-phenoxy isoquinoline-3-formate, is provided, wherein substituent definitions are as defined in the specification. The preparation method comprises the following steps of: under an acidic condition, dissolving a compound shown as a structural formula III in dimethyl sulfoxide, catalyzing by a ferrous ion (Fe) catalyst, and oxidizing by H2O2 to obtain the 4-hydroxy-1-methyl- 7-phenoxy isoquinoline-3-formate shown as the structuralformula II. By using the method, the production efficiency can be greatly improved, the production cost is reduced, the product purity can be ensured, and the method is suitable for industrial mass production.

IMPROVED PROCESS FOR THE PREPARATION OF ROXADUSTAT

A synthetic route for the preparation of Roxadustat, or a pharmaceutically acceptable salt thereof. Each route involves several novel intermediates and avoids the use of column chromatography.