57916-08-2

Basic information

• Product Name: 3-CHLORO-6-BROMO INDOLE
• Synonyms: 3-CHLORO-6-BROMO INDOLE;6-bromo-3-chloro-indole;6-bromo-3-chloro-1H-indole（WS204191）
• CAS NO: 57916-08-2
• Molecular Formula: C₈H₅BrClN
• Molecular Weight: 230.49
• Mol File: 57916-08-2.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-CHLORO-6-BROMO INDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-6-BROMO INDOLE(57916-08-2)
• EPA Substance Registry System: 3-CHLORO-6-BROMO INDOLE(57916-08-2)

Safety Data

• Hazardous Substances Data: 57916-08-2(Hazardous Substances Data)

Upstream product

• 52415-29-9 6-bromo-1H-indole 

Relevant articles and documents

N-Arylsulfonylsubstituted-1H indole derivatives as small molecule dual inhibitors of signal transducer and activator of transcription 3 (STAT3) and tubulin

Signal transducer and activator of transcription (STAT3) is a proposed therapeutic target for the development of anti-cancer agents. In this report, a series of N-arylsulfonylsubstituted-1H indole derivatives were designed and synthesized as STAT3 inhibitors, their anti-proliferative activities were evaluated against a number of tumor cells, some potent compounds exhibited IC50 values less than 10 μM. The most potent compound 4a was further confirmed to inhibit STAT3 phosphorylation at Tyr705. It was further revealed that 4a arrested the cell cycle at the G2/M phase and inhibited tubulin polymerization. This study describes a series of N-arylsulfonylsubstituted-1H indole derivatives as potent anti-cancer agents targeting both STAT3 and tubulin.

NOVEL COMPOUNDS

The present invention relates to novel NADPH oxidase II inhibitors and their use in the treatment of diseases mediated by the NADPH oxidase enzymes.