57928-96-8

Basic information

• Product Name: 4-(2-hydroxyethoxy)benzonitrile
• Synonyms: 4-(2-hydroxyethoxy)benzonitrile;UKRORGSYN-BB BBV-076375
• CAS NO: 57928-96-8
• Molecular Formula: C₉H₉NO₂
• Molecular Weight: 163.17
• Mol File: 57928-96-8.mol
• Article Data: 8

Chemical Properties

• Melting Point: 87.5 °C(Solv: benzene (71-43-2))
• Boiling Point: 345.9±17.0 °C(Predicted)
• Appearance: /
• Density: 1.19±0.1 g/cm3(Predicted)
• PKA: 14.18±0.10(Predicted)
• CAS DataBase Reference: 4-(2-hydroxyethoxy)benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-hydroxyethoxy)benzonitrile(57928-96-8)
• EPA Substance Registry System: 4-(2-hydroxyethoxy)benzonitrile(57928-96-8)

Safety Data

• Hazardous Substances Data: 57928-96-8(Hazardous Substances Data)

Usage

General Description

4-(2-hydroxyethoxy)benzonitrile, also known as HG-531, is a chemical compound commonly used as a UV absorber in various personal care and cosmetic products, as well as in plastics and adhesives. It belongs to the class of phenyl benzonitriles and is a colorless to pale yellow liquid. It is known for its ability to absorb UV light and protect products from photodegradation caused by sun exposure. This makes it a valuable ingredient in sunscreen, moisturizers, and other sun care products. Additionally, it has also been used as a stabilizer in plastics and adhesives to prevent degradation from UV exposure. However, there are some concerns about its potential health risks, and it is important to use products containing this chemical in a safe and controlled manner.

Upstream product

• 75-21-8 oxirane 
• 141-52-6 sodium ethanolate 
• 767-00-0 4-cyanophenol 
• 96-49-1 [1,3]-dioxolan-2-one 
• 107-07-3 2-chloro-ethanol 
• 540-51-2 2-bromoethanol 
• 3328-57-2 sodium 4-cyanophenolate 

Downstream Products

• 182964-58-5 2-[4-(aminomethyl)phenoxy]ethanol 
• 1412334-24-7 C₂₅H₃₁NO₅ 
• 1412334-19-0 C₁₂H₁₅NO₂ 
• 1095130-53-2 C₁₂H₁₁NO₂ 
• 710334-15-9 N-[4-(2-hydroxy-ethoxy)-benzyl]-3,5-dimethyl-benzamide 
• 57323-80-5 4-(2-hydroxy-ethoxy)-benzamidine 

Relevant articles and documents

Revisiting Hydroxyalkylation of Phenols with Cyclic Carbonates

Described is a tetrabutylammonium fluoride-mediated hydroxyalkylation reaction of phenols with cyclic carbonates. This operationally simple method enables the synthesis of a variety of aryl β-hydroxyethyl ethers in good to excellent yields with a very small amount of catalyst loading (0.1–1 mol%). Of particular note is the efficient conversion of aromatic diols and phloroglucinol to the corresponding bis- and tris-hydroxyethylated products. To further showcase the versatility of this protocol, guaifenesin was prepared with a single step by the condensation of guaiacol and glycerol carbonate. We also developed a flow ethoxylation process permitting the continuous synthesis of multiflorol. (Figure presented.).

Novel gambogic acid class derivative and preparation method and application thereof

The invention belongs to the technical field of antitumor drug preparation and discloses a novel gambogic acid class derivative and a preparation method and application thereof. The derivative of the structure mainly modifies gambogic acid C-30, and a plu

A switchable ferrocene-based [1]rotaxane with an electrochemical signal output

A [1]rotaxane, in which a linear rod is attached to one cyclopentadienyl (Cp) ring of a ferrocene unit and threaded into a dibenzo-24-crown-8 connected to the other Cp ring, was prepared. The mechanical motion of the rod-like part relative to the macrocycle has been demonstrated using 1H NMR spectroscopy. Cyclic voltammetry (CV) showed that the system can be chemically switched between electrochemically reversible and irreversible states, depending on the inclusion and exclusion of the ammonium/amine group from the macrocycle.