57943-11-0Relevant articles and documents
Antibacterial and antitubercular activity of fosmidomycin, FR900098, and their lipophilic analogs
Uh, Eugene,Jackson, Emily R.,San Jose, Géraldine,Maddox, Marcus,Lee, Robin E.,Lee, Richard E.,Boshoff, Helena I.,Dowd, Cynthia S.
, p. 6973 - 6976 (2011)
The nonmevalonate pathway (NMP) of isoprene biosynthesis is an exciting new route toward novel antibiotic development. Inhibitors against several enzymes in this pathway are currently under examination. A significant liability of many of these agents is p
COMPOUNDS FOR INHIBITING 1- DEOXY-D-XYLULOSE- 5 - PHOSPHATE REDUCTOISOMERASE
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Paragraph 0075, (2013/03/26)
[0082] In particular, the compound is effective to inhibit Dxr in Mycobacterium tuberculosis (Mtb). The present invention relates to compounds having general formula (I) or where X is an acidic group, such as carboxylate, phosphonate, sulfate, and tetrazole; Ar is a substituted or unsubstituted aromatic or heteroaromatic group; and n is 0, 1, 2, 3, or 4, preferably 2, 3, or 4. The compounds inhibits l-deoxy-D-xylulose-5-phosphate reductoisomerase (Dxr), particularly Dxr in Mycobacterium tuberculosis (Mtb).