5796-14-5

Basic information

• Product Name: 3-hydroxy-L-tyrosine hydrochloride
• Synonyms: 3-hydroxy-L-tyrosine hydrochloride;3-hydroxy- L-Tyrosine hydrochloride (1:1)
• CAS NO: 5796-14-5
• Molecular Formula: C₉H₁₁NO₄*ClH
• Molecular Weight: 233.64888
• EINECS: 227-342-5
• Mol File: 5796-14-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 448.4°Cat760mmHg
• Flash Point: 225°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 7.97E-09mmHg at 25°C
• CAS DataBase Reference: 3-hydroxy-L-tyrosine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 3-hydroxy-L-tyrosine hydrochloride(5796-14-5)
• EPA Substance Registry System: 3-hydroxy-L-tyrosine hydrochloride(5796-14-5)

Safety Data

• Hazardous Substances Data: 5796-14-5(Hazardous Substances Data)

Usage

General Description

3-hydroxy-L-tyrosine hydrochloride is a chemical compound that is derived from the amino acid tyrosine. It is often used as a dietary supplement and has been studied for its potential health benefits, including its ability to support brain health and cognitive function. 3-hydroxy-L-tyrosine hydrochloride is also a precursor to various neurotransmitters, such as dopamine, norepinephrine, and epinephrine, which play important roles in mood regulation and stress response. Additionally, it has been investigated for its potential anti-inflammatory and antioxidant properties. Overall, 3-hydroxy-L-tyrosine hydrochloride may have promising applications in the field of nutrition and health.

InChI:InChI=1/C9H11NO4.ClH/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5;/h1-2,4,6,11-12H,3,10H2,(H,13,14);1H/t6-;/m0./s1

Upstream product

• 139-85-5 3,4-dihydroxybenzaldehyde 
• 59-92-7 levodopa 

Downstream Products

• 137018-93-0 N-(9-fluorenylmethyloxycarbonyl)-3,4-dihydroxy-L-phenylalanine 
• 881911-33-7 (S)-3-(3,4-bis-trityloxy-phenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionic acid 

Relevant articles and documents

Synthesis of a Photo-Caged DOPA Derivative by Selective Alkylation of 3,4-Dihydroxybenzaldehyde

Natural and synthetic polymers containing the catechol moiety of noncoded amino acid 3,4-dihydroxyphenylalanine (DOPA) are capable of metal-coordination and adhesion under wet conditions. Masking the catechol subunit with a photo-cleavable group would provide an opportunity to design tunable adhesion properties that are especially important for biomaterial and biomedicine applications. Herein, we report the regioselective synthesis of a photo-caged DOPA bearing an ortho-nitrobenzyl (oNB) group that is capable of undergoing cleavage upon irradiation with UV light. We developed a selective synthetic route towards a 3-O-oNB alkylated DOPA regioisomer that can be readily incorporated into proteins by using a previously developed bio-expression platform. The synthesis is based on a regioselectivity switch in 3,4-dihydrozybenzaldehyde alkylation upon application of different equivalents of deprotonating base. The enantiomerically pure 3-O-oNB-DOPA was prepared on a gram scale and proved to be generally compatible with the solid-phase peptide synthesis conditions. We also demonstrate the general applicability of the developed synthetic strategy by providing the synthesis of 3-O-methyl-DOPA.

NOVEL HYDROCHLORIDE SALTS OF LEVODOPA

The present invention provides a novel hydrochloride salt of levodopa. In addition, pharmaceutical compositions comprising said hydrochloride salt of levodopa may be used as fast-dissolve compositions. Methods of making and of using the same are also provided.