57999-49-2

Basic information

• Product Name: 2-(3-BROMOPHENOXY)TETRAHYDRO-2H-PYRAN
• Synonyms: 2-(3'-BROMOPHENOXY)TETRAHYDRO-2H-PYRAN;2-(3-BROMOPHENOXY)TETRAHYDRO-2H-PYRAN;2-(3'-BROMOPHENOXY)-TETRAHYDROPYRANYL ETHER;2-(3-BROMOPHENOXY)TETRAHYDROPYRAN;3-(Tetrahydropyran-2-yloxy)phenyl bromide;3-Bromophenyl tetrahydro-2H-pyran-2-yl ether;2-(3-Bromophenoxy)tetrahydropyran 3-(Tetrahydropyran-2-yloxy)phenyl bromide
• CAS NO: 57999-49-2
• Molecular Formula: C₁₁H₁₃BrO₂
• Molecular Weight: 257.12
• EINECS: 145-693-6
• Product Categories: Aromatic Ethers;Bromine Compounds;Miscellaneous Compounds;Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Pyrans;PyransHeterocyclic Building Blocks;Building Blocks;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks;Furans
• Mol File: 57999-49-2.mol
• Article Data: 8

Chemical Properties

• Melting Point: 42-46 °C(lit.)
• Boiling Point: 322.4 °C at 760 mmHg
• Flash Point: >230 °F
• Appearance: UN 3077
• Density: 1.403±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0.000527mmHg at 25°C
• Refractive Index: 1.5504 (589.3 nm 20℃)
• CAS DataBase Reference: 2-(3-BROMOPHENOXY)TETRAHYDRO-2H-PYRAN(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-BROMOPHENOXY)TETRAHYDRO-2H-PYRAN(57999-49-2)
• EPA Substance Registry System: 2-(3-BROMOPHENOXY)TETRAHYDRO-2H-PYRAN(57999-49-2)

Safety Data

• Hazard Codes: N,Xn
• Statements: 51-53-36/37/38-20/21/22-51/53
• Safety Statements: 61-36-26
• RIDADR: UN 3077 9/PG 3
• WGK Germany: 3
• Hazardous Substances Data: 57999-49-2(Hazardous Substances Data)

Usage

General Description

2-(3-Bromophenoxy)tetrahydro-2H-pyran, also known as brompheniramine, is a chemical compound with the molecular formula C16H19BrO2. It is commonly used as an antihistamine and a mild sedative to relieve symptoms of allergies, hay fever, and the common cold. Brompheniramine works by blocking the action of histamine, a substance in the body that causes allergic symptoms. It is often found in over-the-counter medications and is generally well-tolerated, although it may cause drowsiness or dizziness in some individuals. The compound is stable under normal conditions and should be handled with appropriate safety precautions.

InChI:InChI=1/C11H13BrO2/c12-9-4-3-5-10(8-9)14-11-6-1-2-7-13-11/h3-5,8,11H,1-2,6-7H2

Upstream product

• 110-87-2 3,4-dihydro-2H-pyran 
• 591-20-8 3-Bromophenol 

Downstream Products

• 875273-45-3 1-benzyl-3-[3-(tetrahydropyran-2-yloxy)-phenyl]-piperidin-3-ol 
• 1207067-33-1 C₂₃H₂₂FNO₄ 
• 83647-26-1 1-[4-(2-Dimethylamino-ethoxy)-phenyl]-2-phenyl-1-[3-(tetrahydro-pyran-2-yloxy)-phenyl]-butan-1-ol 
• 142402-62-8 (3-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)magnesium bromide 

Relevant articles and documents

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1-Benzyl-4-phenyl-1H-1,2,3-triazoles improve the transcriptional functions of estrogen-related receptor γ and promote the browning of white adipose

The estrogen-related receptor γ (ERRγ) is a potential molecular target for the development of small molecules to stimulate the adipose browning process, which may represent a novel attractive strategy to treat obesity related disorders. The receptor possesses a very small ligand binding cavity and therefore identification of small molecule ERRγ modulators is a considerable challenge. We have successfully designed and synthesized a series of 1-benzyl-4-phenyl-1H-1,2,3-triazoles and demonstrated that they improve the transcriptional functions of ERRγ, potently elevating both the mRNA levels and the protein levels of ERRγ downstream targets. One of the most promising compounds, 4-(1-(4-iso-propylbenzyl)-1H-1,2,3-triazol-4-yl)benzene-1,2-diol (2e) was further shown to directly bind with the ERRγ ligand binding domain (ERRγ-LBD) in an isothermal calorimetric (ITC) assay and to thermally stabilize ERRγ-LBD protein by increasing its melting temperature (Tm) as demonstrated by circular dichroism (CD) spectroscopy. Furthermore, 2e potently stimulates the adipocyte browning process and induces mitochondrial biogenesis both in vitro and in vivo, suggesting the considerable therapeutic potential of this compound for the treatment of obesity and related disorders.

Traceless solid-phase synthesis of trifluoromethylarenes

Save the best for last: In the first method for the trifluoromethylation of immobilized arenes, the aryl halides are attached through a dithioester linkage to the Merrifield resin and then functionalized by means of numerous reactions including transition