58-38-8 Usage
Description
Prochlorperazine is a member of the phenothiazine class, specifically a 10H-phenothiazine with a chloro substituent at the 2-position and a 3-(4-methylpiperazin-1-yl)propyl group at the N-10 position. It is known by the brand name Compazine, manufactured by GlaxoSmithKline.
Uses
Used in Pharmaceutical Industry:
Prochlorperazine is used as an antiemetic for the treatment of nausea and vomiting. It helps to alleviate these symptoms by blocking the action of certain chemicals in the brain that may cause these issues.
Used in Mental Health Applications:
Prochlorperazine is used as an antipsychotic to manage the symptoms of psychotic disorders, such as schizophrenia. It works by helping to restore the balance of certain natural substances in the brain, providing relief from hallucinations, delusions, and disorganized thinking.
Used in Treatment of Vertigo:
Prochlorperazine is used to treat vertigo, a sensation of spinning or dizziness that may be caused by various factors, such as inner ear problems or migraines. It helps to alleviate the symptoms by affecting the part of the brain responsible for controlling balance and spatial orientation.
Clinical Use
Nausea and vomiting
Labyrinthine disorders
Psychoses
Severe anxiety
Safety Profile
Poison by ingestion,
subcutaneous, intravenous, and
intraperitoneal routes. Experimental
teratogenic and reproductive effects. Human
systemic effects by ingestion: headache,
blood pressure elevation. Implicated in
aplastic anemia. When heated to
decomposition it emits very toxic fumes of
SOx, NOx, and Cl-.
Veterinary Drugs and Treatments
Prochlorperazine as a single agent is used in dogs and cats as an antiemetic.
The only approved products for animals are combination
products containing prochlorperazine, isopropamide, with or without
neomycin (Darbazine?, Neo-Darbazine?—SKB Labs) which
are no longer marketed in the USA. The approved indications for
these products include: vomiting, non-specific gastroenteritis, drug
induced diarrhea, infectious diarrhea, spastic colitis, and motion
sickness in dogs and cats (injectable product only).
Drug interactions
Potentially hazardous interactions with other drugs
Anaesthetics: enhanced hypotensive effect.
Analgesics: increased risk of convulsions with
tramadol; enhanced hypotensive and sedative
effects with opioids; increased risk of ventricular
arrhythmias with methadone.
Anti-arrhythmics increased risk of ventricular
arrhythmias with anti-arrhythmics that prolong
the QT interval, e.g. procainamide, disopyramide,
dronedarone and amiodarone - avoid with
amiodarone and dronedarone.
Antibacterials: increased risk of ventricular
arrhythmias with delamanid and moxifloxacin -
avoid.
Antidepressants: increase concentrations and
additive antimuscarinic effects, notably with
tricyclics; increased risk of ventricular arrhythmias
with citalopram and escitalopram - avoid; increased
risk of convulsions with vortioxetine.
Antiepileptics: antagonised (convulsive threshold
lowered).
Antimalarials: avoid with artemether/lumefantrine
and piperaquine with artenimol.
Antipsychotics: increased risk of ventricular
arrhythmias with droperidol and pimozide - avoid;
increased risk of ventricular arrhythmias with
risperidone.
Antivirals: concentration possibly increased with
ritonavir; increased risk of ventricular arrhythmias
with saquinavir - avoid.
Anxiolytics and hypnotics: increased sedative effects.
Atomoxetine: increased risk of ventricular
arrhythmias.
Beta-blockers: enhanced hypotensive effect;
increased risk of ventricular arrhythmias with sotalol.
Cytotoxics: increased risk of ventricular arrhythmias
with arsenic trioxide.
Desferrioxamine: avoid concomitant use.
Diuretics: enhanced hypotensive effect.
Lithium: increased risk of extrapyramidal side effects
and possibly neurotoxicity.
Pentamidine: increased risk of ventricular
arrhythmias.
Metabolism
Prochlorperazine undergoes extensive first pass
metabolism in the gut wall. It is also extensively
metabolised in the liver and is excreted in the urine and
bile. The metabolites are inactive.
Check Digit Verification of cas no
The CAS Registry Mumber 58-38-8 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 5 and 8 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 58-38:
(4*5)+(3*8)+(2*3)+(1*8)=58
58 % 10 = 8
So 58-38-8 is a valid CAS Registry Number.
InChI:InChI=1/C20H24ClN3S/c1-22-11-13-23(14-12-22)9-4-10-24-17-5-2-3-6-19(17)25-20-8-7-16(21)15-18(20)24/h2-3,5-8,15H,4,9-14H2,1H3
58-38-8Relevant articles and documents
A preparation method of the third chlorine pulls qin
-
Paragraph 0026; 0028; 0031, (2018/10/11)
The invention discloses a method for preparing the third chlorine pulls qin, has changed the existing method of the reaction sequence, the first to use 1 - bromo - 3 - chloro propane and 2 - chloro phenothiazine reaction, further with the third chlorine pulls qin N - methyl piperazine is generated by the reaction. This invention discloses technology can not complete reaction lead to reaction the cost is high, and has a gene toxic impurities to make the final purity of the product is difficult to achieve the medical-grade technical defect.