58046-50-7

Basic information

• Product Name: 5-amino-1-(2-hydroxyethyl)pyrazole-4-carboxylic acid
• Synonyms: 5-amino-1-(2-hydroxyethyl)pyrazole-4-carboxylic acid;5-Amino-1-(2-hydroxyethyl)-1H-pyrazole-4-carboxylic acid;5-(2-aMino-2-hydroxyethyl)-1H-pyrazole-4-carboxylic acid
• CAS NO: 58046-50-7
• Molecular Formula: C6H9N3O3
• Molecular Weight: 171.16
• Mol File: 58046-50-7.mol
• Article Data: 3

Chemical Properties

• Melting Point: 145-146 °C (decomp)
• Boiling Point: 461.1 °C at 760 mmHg
• Flash Point: 232.7 °C
• Appearance: /
• Density: 1.63 g/cm³
• Vapor Pressure: 2.68E-09mmHg at 25°C
• Refractive Index: 1.67
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 4.58±0.10(Predicted)
• CAS DataBase Reference: 5-amino-1-(2-hydroxyethyl)pyrazole-4-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-amino-1-(2-hydroxyethyl)pyrazole-4-carboxylic acid(58046-50-7)
• EPA Substance Registry System: 5-amino-1-(2-hydroxyethyl)pyrazole-4-carboxylic acid(58046-50-7)

Safety Data

• Hazardous Substances Data: 58046-50-7(Hazardous Substances Data)

Usage

General Description

5-amino-1-(2-hydroxyethyl)pyrazole-4-carboxylic acid, also known as AHPC, is a chemical compound with a molecular formula C7H10N2O4. It is a pyrazole derivative with a carboxylic acid group and an amino group, as well as a hydroxyethyl side chain. AHPC has been studied for its potential role as a ligand in coordination chemistry and as a chelating agent for metal ions. It has also been investigated for its pharmaceutical properties, particularly as a potential drug candidate for the treatment of various diseases. Additionally, AHPC may have applications in organic synthesis and material science due to its unique chemical structure and reactivity.

InChI:InChI=1/C6H9N3O3/c7-5-4(6(11)12)3-8-9(5)1-2-10/h3,10H,1-2,7H2,(H,11,12)

Upstream product

• 109-84-2 2-hydroxyethylhydrazine 
• 16849-87-9 2-(4b-dimethylaminomethylene)-2-cyano ethyl acetate 
• 1187-27-5 2-cyano-3-dimethylamino acrylate 

Downstream Products

• 73616-27-0 5-amino-1-(2-hydroxyethyl)-1H-pyrazole 

Relevant articles and documents

Synthesis method of N-hydroxyethyl-5-amino-1H pyrazole

The invention discloses a synthesis method of N-hydroxyethyl-5-amino-1H pyrazole. The synthesis method comprises the following steps: by taking N, N-dimethylformamide as a raw material, carrying out one-pot reaction on the N, N-dimethylformamide, dimethyl sulfate and cyanoacetic acid R ester to prepare 2-cyano-3-(dimethylamino) acrylic acid R ester; carrying out cyclization and hydrolysis on the 2-cyano-3-(dimethylamino) acrylic acid R ester and beta-hydroxyethylhydrazine to prepare N-hydroxyethyl-5-amino-1H pyrazole-4-formic acid; and carrying out decarboxylation on N-hydroxyethyl-5-amino-1H pyrazole-4-formic acid, so as to prepare N-hydroxyethyl-5-amino-1H pyrazole, wherein R is an alkane group below C4. The synthesis method provided by the invention has the advantages of strong operability, high economic benefit and high yield.

Preparation of 4,5-diamino-1-(2′-hydroxyethyl)-pyrazole and acid addition salts thereof

Disclosed is an improved process for the preparation of 4,5-diamino-1-(2′-hydroxyethyl)pyrazole and acid addition salts thereof such as the addition salt from sulfuric acid. The process comprises a novel combination of steps beginning with an alkyl(alkoxymethylene)cyanoacetate and 2-hydroxyethylhydrazine and the formation of intermediate compounds 5-amino-4-alkoxycarbonyl-1-(2′-hydroxyethyl)pyrazole (I), 5-amino-4-carboxyl-1-(2′-hydroxyethyl)pyrazole (II), 5-amino-1-(2′-hydroxyethyl)pyrazole (III), 5-amino-1-(2′-hydroxyethyl)4-nitrosopyrazole (IV).