581-96-4

Basic information

• Product Name: 2-Naphthylacetic acid
• Synonyms: LABOTEST-BB LT00408955;AKOS BBS-00007768;2-NAPHTHYLACETIC ACID;2-NAPHTHALENEACETIC ACID;RARECHEM AL BO 0200;NAPHTHALENE-2-ACETIC ACID;β-Naphthylene acetic acid;.beta.-Naphthaleneacetate
• CAS NO: 581-96-4
• Molecular Formula: C₁₂H₁₀O₂
• Molecular Weight: 186.21
• EINECS: 209-475-0
• Product Categories: Pharmaceutical Raw Materials;Naphthalene derivatives;Organic acids;Building Blocks;C11 to C12;Carbonyl Compounds;Carboxylic Acids;Chemical Synthesis;Organic Building Blocks;Naphthalene series
• Mol File: 581-96-4.mol
• Article Data: 48

Chemical Properties

• Melting Point: 141-143 °C(lit.)
• Boiling Point: 280.69°C (rough estimate)
• Flash Point: 270.1 °C
• Appearance: White to almost white/Crystalline Powder or Flakes
• Density: 1.1032 (rough estimate)
• Vapor Pressure: 3.13E-06mmHg at 25°C
• Refractive Index: 1.6010 (estimate)
• Storage Temp.: Store below +30°C.
• Solubility: acetone: 50 mg/mL, clear
• PKA: pK1:4.256 (25°C)
• Water Solubility: insoluble
• BRN: 973396
• CAS DataBase Reference: 2-Naphthylacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Naphthylacetic acid(581-96-4)
• EPA Substance Registry System: 2-Naphthylacetic acid(581-96-4)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36-24/25
• WGK Germany: 3
• RTECS: QJ0876000
• HazardClass: IRRITANT
• Hazardous Substances Data: 581-96-4(Hazardous Substances Data)

Usage

Chemical Properties

WHITE TO ALMOST WHITE CRYST. POWDER OR FLAKES

Uses

2-Naphthylacetic acid can be used to synthesize hydrolase inhibitors. It can also be utilized for developing?γ-dipeptide derivatives that can bind human somatostatin receptors.

Purification Methods

Crystallise the acid from water or *benzene. [Beilstein 9 H 666, 9 IV 2431.]

InChI:InChI=1/C12H10O2/c13-12(14)8-9-5-6-10-3-1-2-4-11(10)7-9/h1-7H,8H2,(H,13,14)/p-1

Upstream product

• 60-29-7 diethyl ether 
• 15719-64-9 methylammonium carbonate 
• 7498-57-9 2-naphthaleneacetonitrile 
• 36660-46-5 2-(naphthalene-2-yl)-acetamide 
• 111726-64-8 3-(naphthalene-2-yl)-2-oxopropanoic acid 
• 201230-82-2 carbon monoxide 
• 2506-41-4 1-chloromethylnaphthalene 
• 939-26-4 2-bromomethylnaphthyl bromide 
• 613-54-7 2-Bromo-2'-acetonaphthone 
• 1485-07-0 naphthalen-2-ethanol 
• 2876-70-2 ethyl 2-naphthylacetate 
• 64-18-6 formic acid 
• 124-38-9 carbon dioxide 
• 1416982-18-7 N,N,N-trimethyl-1-(naphthalen-2-yl)methanaminium trifluoromethanesulfonate 

Downstream Products

• 127035-93-2 2,6-Dimethyl-4-((E)-2-naphthalen-2-yl-vinyl)-phenol 
• 130553-61-6 N-Methyl-2-naphthalen-2-yl-N-((1R,2S)-2-pyrrolidin-1-yl-cyclohexyl)-acetamide 
• 130609-90-4 1S,2R-cis-(-)-N-methyl-N-<2-(1-pyrrolidinyl)cyclohexyl>-(2-naphthyl)acetamide 
• 130609-91-5 1R,2S-cis-(+)-N-methyl-N-<2-(1-pyrrolidinyl)cyclohexyl>-(2-naphthyl)acetamide 
• 134405-49-5 (E)-3-[2-n-Butyl-1-{(2-chlorophenyl)methyl}-1H-imidazol-5-yl]-2-(2-naphthyl)-2-propenoic Acid 
• 110191-43-0 4-Benzyloxy-7-methyl-2-naphthalen-2-ylmethyl-1H-benzoimidazole 
• 66-99-9 β-naphthaldehyde 
• 38503-47-8 (E)-2-(3-methylstyryl)naphthalene 
• 95277-19-3 2-(naphthalen-2-yl)-3-phenylacrylic acid 
• 250142-41-7 4-nitrophenyl 2-(naphthalen-2'-yl)acetate 

Relevant articles and documents

HIGH PURITY 2-NAPHTHYLACETONITRILE AND METHOD FOR PRODUCING SAME

-

METHOD FOR MANUFACTURING AROMATIC NITRILE COMPOUND

The present invention provides a method for industrially producing a highly pure aromatic nitrile compound and a highly pure aromatic carboxylic acid compound safely and highly efficiently at low costs. Compound (2) is subjected to Willgerodt reaction in the presence of an additive as necessary, and the obtained amide compound (3) is hydrolyzed and neutralized to give carboxylic acid compound (4). Carboxylic acid compound (4) is reacted with a halogenating agent in the presence of a catalyst as necessary in an organic solvent, and further reacted with an amidating agent, and the obtained amide compound (5) or (6) is reacted with a dehydrating agent to give nitrile compound (1). Alternatively, carboxylic acid compound (4) is reacted with a halogenating agent and a compound represented by the formula R6SO2R7 in the presence of a catalyst as necessary in an organic solvent to give nitrile compound (1). Np is a naphthyl group optionally having substituent(s), R5 is an alkylene group having 1-3 carbon atoms, and other symbols are as described in the DESCRIPTION.

Pd(OH)2/C, a Practical and Efficient Catalyst for the Carboxylation of Benzylic Bromides with Carbon Monoxide

A simple, efficient, cheap, and broadly applicable system for the carboxylation of benzylic bromides with carbon monoxide and water is reported. Upon simple reaction with only 2.5 wt % of Pearlman's catalyst and 10 mol % of tetrabutylammonium bromide in tetrahydrofuran at 110 °C for 4 h, a range of benzylic bromides can be smoothly converted to the corresponding arylacetic acids in good to excellent yields after simple extraction and acid-base wash. The reaction was found to be broadly applicable, scalable, and could be successfully extended to the use of ex situ-generated carbon monoxide and applied to the synthesis of the nonsteroidal anti-inflammatory drug diclofenac.