58139-11-0

Basic information

• Product Name: 2,3'-DIFLUOROBENZOPHENONE
• Synonyms: 2,3'-DIFLUOROBENZOPHENONE;(2-Fluorophenyl)(3-fluorophenyl)Methanone
• CAS NO: 58139-11-0
• Molecular Formula: C13H8F2O
• Molecular Weight: 218.2
• Mol File: 58139-11-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 177°C 16mm
• Flash Point: 127 °C
• Appearance: /
• Density: 1.239 g/cm³
• Vapor Pressure: 0.000158mmHg at 25°C
• Refractive Index: 1.549
• CAS DataBase Reference: 2,3'-DIFLUOROBENZOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3'-DIFLUOROBENZOPHENONE(58139-11-0)
• EPA Substance Registry System: 2,3'-DIFLUOROBENZOPHENONE(58139-11-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 58139-11-0(Hazardous Substances Data)

Usage

General Description

2,3'-Difluorobenzophenone is a chemical compound with the molecular formula C13H8F2O. It is a white solid that is insoluble in water but soluble in organic solvents. 2,3'-DIFLUOROBENZOPHENONE is commonly used as a building block in the synthesis of various pharmaceuticals and agrochemicals. It is also used as a photoinitiator in the production of polymer coatings and adhesives. Additionally, 2,3'-Difluorobenzophenone has applications in the manufacture of dyes, pigments, and other specialty chemicals. 2,3'-DIFLUOROBENZOPHENONE is considered to have low to moderate toxicity and adverse health effects are primarily associated with exposure through inhalation or skin contact. Overall, 2,3'-Difluorobenzophenone is a versatile chemical with diverse industrial applications.

InChI:InChI=1/C13H8F2O/c14-10-5-3-4-9(8-10)13(16)11-6-1-2-7-12(11)15/h1-8H

Upstream product

• 17318-03-5 bromo(3-fluorophenyl)magnesium 
• 393-52-2 2-Fluorobenzoyl chloride 
• 19226-36-9 3-phenyl-5H-1,4,2-dioxazol-5-one 

Relevant articles and documents

Continuous flow synthesis of diaryl ketones by coupling of aryl Grignard reagents with acyl chlorides under mild conditions in the ecofriendly solvent 2-methyltetrahydrofuran

An efficient continuous flow sequential synthesis of diaryl ketones was achieved by coupling of aryl Grignard reagents with acyl chlorides in the bio-derived “green” solvent 2-methyltetrahydrofuran (2-MeTHF) under mild reaction conditions (ambient temperature, 1 hour), allowing a safe and on-demand generation of 2-(3-benzoylphenyl)propionitrile with a productivity of 3.16 g hour?1

Co(III)-Catalyzed Synthesis of Quinazolines via C-H Activation of N-Sulfinylimines and Benzimidates

C-H activation of arenes has been established as an important strategy for heterocycle synthesis via annulations between arenes and unsaturated coupling partners. However, nitriles failed to act as such a coupling partner. Dioxazolones have been employed as a synthon of nitriles, and subsequent coupling with arenes such as N-sulfinylimines and benzimidates bearing a functionalizable directing group provided facile access to two classes of quinazolines under Co(III)-catalysis.