58166-38-4Relevant articles and documents
Improved method for synthesis of cysteine modified hyaluronic acid for in situ hydrogel formation
Zhang, Xin,Sun, Pengcheng,Huangshan, Lingzi,Hu, Bi-Huang,Messersmith, Phillip B.
, p. 9662 - 9665 (2015)
We developed a new strategy for the functionalization of hyaluronic acid by chemical modification of its C-6 hydroxyl groups through an ether bond to obtain a cysteine-hyaluronic acid conjugate. This conjugate is suitable to prepare injectable and in situ formed hydrogels cross-linked by native chemical ligation and Michael addition under mild conditions.
SOLUTION PHASE ROUTES FOR WNT HEXAPEPTIDES
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Page/Page column 17; 18, (2020/12/30)
The present disclosure relates generally to the field of polypeptide synthesis, and more particularly, to the solution phase synthesis of the Wnt hexapeptide Foxy-5 and protected derivatives and peptide fragments thereof.
Curcumin analog cytotoxicity against breast cancer cells: exploitation of a redox-dependent mechanism
Sun, Aiming,Lu, Yang J.,Hu, Haipeng,Shoji, Mamoru,Liotta, Dennis C.,Snyder, James P.
scheme or table, p. 6627 - 6631 (2010/06/14)
A series of novel curcumin analogs, symmetrical dienones, were previously shown to possess cytotoxic, anti-angiogenic and anti-tumor activities. Analogs 1 (EF24) and 2 (EF31) share the dienone scaffold and serve as Michael acceptors. We propose that the anti-cancer effects of 1 and 2 are mediated in part by redox-mediated induction of apoptosis. In order to support this concept, 1 and 2 were treated with l-glutathione (GSH) and cysteine-containing dipeptides under mild conditions to form colorless water-soluble adducts, which were identified by LC/MS. Comparison of the cytotoxic action of 1, 2 and the corresponding conjugates, 1-(GSH)2 and 2-(GSH)2, illustrated that the two classes of compounds exhibit essentially identical cell killing capabilities. Compared with the yellow, somewhat light sensitive and nearly water insoluble compounds 1 and 2, the glutathione conjugates represent a promising new series of stable and soluble anti-tumor pro-drugs.