58167-41-2

Basic information

• Product Name: Ethylthio, 2-amino-2-carboxy-1,1-dimethyl-, (R)-
• CAS NO: 58167-41-2
• Molecular Formula: C5H10NO2S
• Molecular Weight: 148.206
• Mol File: 58167-41-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Ethylthio, 2-amino-2-carboxy-1,1-dimethyl-, (R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethylthio, 2-amino-2-carboxy-1,1-dimethyl-, (R)-(58167-41-2)
• EPA Substance Registry System: Ethylthio, 2-amino-2-carboxy-1,1-dimethyl-, (R)-(58167-41-2)

Safety Data

• Hazardous Substances Data: 58167-41-2(Hazardous Substances Data)

Upstream product

• 1113-41-3 L-penicillamine 
• 3250-66-6 1,2-dihydroxy-ethyl 
• 4598-47-4 dioxanyl radical 
• 19426-60-9 tetrahydrofuran-2-yl 
• 5723-77-3 1-hydroxy-propyl 
• 2348-46-1 ethanol radical 

Downstream Products

• 2348-46-1 ethanol radical 
• 1113-41-3 L-penicillamine 
• 5131-95-3 2-hydroxy-2-propyl radical 
• 3250-66-6 1,2-dihydroxy-ethyl 
• 5723-77-3 1-hydroxy-propyl 

Relevant articles and documents

Determination of Absolute Rate Constants for the Reversible Hydrogen-atom Transfer between Thiyl Radicals and Alcohols or Ethers

Absolute rate constants have been determined for the reversible hydrogen-transfer process R. + RSH ->/. by pulse radiolysis, mainly through direct observation of the RS. radical formation kinetics in water-RH (1:1, v/v) mixtures.The thiols investigated were penicillamine and glutathione; the RH hydrogen donors were methanol, ethanol, propan-1-ol, propan-2-ol, ethylene glycol, tetrahydrofuran and 1,4-dioxane with the abstracted hydrogen being located α to the hydroxy or alkoxy function.Rate constants for the forward reaction of the above equilibrium (in radiation biology referred to as 'repair' reaction) were typically of the order of 1E7-1E8 dm3 mol-1 s-1 while hydrogen abstraction from RH by thiyl radicals (reverse process) occurred with rate constants of the order of 1E3-1E4 dm3 mol-1 s-1.This yields equilibrium constants of the order of 1E4.Based on these data, standard reduction potentials could be evaluated for the R'R''C.OH/H(1+)//R'R''CHOH, R'R''CO/H(1+)//R'R''C.(OH) and R'R''CO//R'R''C.O(1-) couples from methanol, ethanol and propan-2-ol.Effective hydrogen-atom abstraction by RS. required activation by neighbouring groups of the C-H bond to be cleaved in RH.No such process was observed for the RS. reaction with -CH3 groups, e.g. in 2-methylpropan-2-ol.Several halogenated hydrocarbons, including some anaesthetics (e.g. halothane) and Fe(CN)6(3-) have been tested with respect to their ability to disturb the (CH3)2C.OH + RSH ->/. equilibrium through an irreversible electron-transfer reaction with the reducing α-hydroxyl radical, thereby drawing the equilibrium to the left-hand side.The respective efficiencies are found to be related to the electronegativities of the electron acceptors.The results are briefly discussed in terms of their biological relevance.