582-04-7Relevant articles and documents
Diversity-oriented synthesis of benzofuro[3,2-b]pyridine derivatives from aurone-derived α,β-unsaturated imines and activated terminal alkynes
Cheng, Bin,He, Yixuan,Li, Hui,Sun, Haiyan,Wang, Taimin,Zhai, Hongbin,Zhang, Xinping,Zhu, Xuecheng
supporting information, p. 7701 - 7704 (2021/08/09)
An efficient annulation reaction of aurone-derived α,β-unsaturated imines and activated terminal alkynes mediated by triethylamine is described, which enables the facile synthesis of 1,4-dihydrobenzofuro[3,2-b]pyridines in high yields. When the nucleophil
Preparation method of benzofurocoumarin compound
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Paragraph 0051-0057; 0153-0157, (2020/11/23)
The invention discloses a preparation method of a photoactive benzofurocoumarin compound. The photoactive benzofurocoumarin compound is a compound shown as a formula I; the enantioselectivity of the compound shown in the formula I is up to 95-99%. The pho
Enantioselective Oxidative Cyclization/Mannich Addition Enabled by Gold(I)/Chiral Phosphoric Acid Cooperative Catalysis
Wei, Hanlin,Bao, Ming,Dong, Kuiyong,Qiu, Lihua,Wu, Bing,Hu, Wenhao,Xu, Xinfang
supporting information, p. 17200 - 17204 (2018/12/05)
An enantioselective Mannich-type reaction of 3-butynol and nitrones is described, which affords dihydrofuran-3-ones in good yields and with excellent enantioselectivities. The reaction is initiated by gold-catalyzed alkyne oxidation and modification of the resulting gold carbene species with a tethered hydroxy group to form enolate species; the reaction terminates with an enantioselective Mannich-type addition with the assistance of chiral phosphoric acid (CPA) and hydrogen bonding. This novel pattern of alkyne transformation involving chemical bond cleavage, and a fragment modification and reassembly process, provides an atom- and step-economic method, and is the first example of cooperative asymmetric catalysis in gold-catalyzed alkyne oxidations via an α-oxo gold carbene route.