58226-81-6Relevant articles and documents
METHODS AND COMPOSITIONS FOR TREATING BETA-THALASSEMIA AND SICKLE CELL DISEASE
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Paragraph 0221; 0222; 0231, (2016/05/19)
Compounds, pharmaceutical compositions, and methods for treating anemia β-thalassemia anemia or sickle cell anemia.
The heterocyclic ring of 4-substituted-1,8-naphthalimides is NOT inert to nucleophilic attack, contrary to earlier reports
McKenney, Ryan K.,Groess, Leah L.,Kopidlansky, Kyle M.,Dunkle, Kelsey L.,Lewis, David E.
, p. 4390 - 4396 (2013/08/23)
The heterocyclic ring of N-aryl-4-chloro-1,8-naphthalimides, reported to be resistant to nucleophilic attack, reacts with primary amine nucleophiles at room temperature to give 4-chloro-N-alkyl-1,8-naphthalimides. The reaction is first order in the naphth