582295-24-7

Basic information

• Product Name: (2S,3R)-2-amino-3-hydroxy-3-(4-nitro-phenyl)-propionic acid ethyl ester
• Synonyms: (2S,3R)-2-amino-3-hydroxy-3-(4-nitro-phenyl)-propionic acid ethyl ester
• CAS NO: 582295-24-7
• Molecular Weight: 254.243
• Mol File: 582295-24-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S,3R)-2-amino-3-hydroxy-3-(4-nitro-phenyl)-propionic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3R)-2-amino-3-hydroxy-3-(4-nitro-phenyl)-propionic acid ethyl ester(582295-24-7)
• EPA Substance Registry System: (2S,3R)-2-amino-3-hydroxy-3-(4-nitro-phenyl)-propionic acid ethyl ester(582295-24-7)

Safety Data

• Hazardous Substances Data: 582295-24-7(Hazardous Substances Data)

Upstream product

• 42267-16-3 (2S,3R)-2-amino-3-hydroxy-3-phenyl-propionic acid ethyl ester; hydrochloride 
• 75414-82-3 ethyl 2-diazo-3-(4-nitrophenyl)-3-oxopropanoate 
• 106270-15-9 (4S)-2-methyl-5t-phenyl-4,5-dihydro-oxazole-4r-carboxylic acid ethyl ester 
• 88854-18-6 (2S,3R)-ethyl 2-acetamido-3-acetoxy-3-phenylpropanoate 
• 129446-45-3 (2S,3R)-2-amino-3-hydroxy-3-(4-aminophenyl)propanoic acid 

Downstream Products

• 119-62-0 (1R,2R)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol 

Relevant articles and documents

An enantioselective synthesis of nitrogen protected 3-arylserine esters

A method for the preparation of (2R,3S) nitrogen protected arylserine esters is described. The method consists of rhodium mediated insertion of tert-butylcarbamate into the corresponding 3-keto-2-diazoester, affording the N-protected α-amino-β-ketoester, followed by asymmetric reduction/dynamic resolution to afford the corresponding N-protected 3-arylserine esters in good chemical yield, and in most cases high enantiomeric excess.