582313-79-9Relevant articles and documents
Synthesis and antihyperglycemic activity of erythrose, ribose and substituted pyrrolidine containing thiazolidinedione derivatives
Kim, Bok Young,Ahn, Joong Bok,Lee, Hong Woo,Moon, Kyoung Sik,Sim, Tae Bo,Shin, Jae Soo,Ahn, Soon Kil,Hong, Chung Il
, p. 276 - 285 (2007/10/03)
A series of erythrose, ribose, and substituted pyrrolidine containing 2,4-thiazolidinediones were synthesized. Among them, thirteen unsaturated thiazolidinediones, six saturated thiazolidinediones and two unsaturated malonates were evaluated for their ability to enhance glucose utilization in cultured L6 myocytes. On the basis of the in vitro activity, 5-{4-[2-(1-benzyl-3,4-bis-benzyloxypyrrolidin-2-yl)ethoxy]benzylidene} thiazolidine-2,4-dione 24b was selected as the candidate for further pharmacological studies.