58249-25-5

Basic information

• Product Name: 1,2-benzisothiazol-3(2H)-one, sodium salt
• Synonyms: 1,2-benzisothiazol-3(2H)-one, sodium salt;1,2-BENZISOTHIAZOLIN-3-ONE SODIUM SALT;1,2-benzisothiazol-3(2H)-one sodiuM;1,2-Benzisothiazol-3(2H)-one,sodiuM salt (1:1);1,2-Benzoisothiazolin-3-one, sodium salt
• CAS NO: 58249-25-5
• Molecular Formula: C₇H₄NOS*Na
• Molecular Weight: 174.17547
• EINECS: 261-184-8
• Product Categories: Industrial/Fine Chemicals
• Mol File: 58249-25-5.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,2-benzisothiazol-3(2H)-one, sodium salt(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-benzisothiazol-3(2H)-one, sodium salt(58249-25-5)
• EPA Substance Registry System: 1,2-benzisothiazol-3(2H)-one, sodium salt(58249-25-5)

Safety Data

• Hazardous Substances Data: 58249-25-5(Hazardous Substances Data)

Usage

General Description

1,2-benzisothiazol-3(2H)-one, sodium salt is a synthetic compound that belongs to the class of isothiazolones. It is commonly used as a biocide, fungicide, and preservative in different industrial and consumer products, such as paints, adhesives, and personal care items. This chemical is known for its strong antimicrobial properties, making it an effective agent against a wide range of microorganisms, including bacteria and fungi. It is typically found in the form of a white or pale yellow crystalline solid and is soluble in water. However, its use and handling should be done with caution due to its potential harmful effects on human health and the environment. Overall, 1,2-benzisothiazol-3(2H)-one, sodium salt is a versatile and potent chemical that serves various industrial applications, particularly in the preservation and protection of products from microbial contamination.

InChI:InChI=1/C7H5NOS.Na/c9-7-5-3-1-2-4-6(5)10-8-7;/h1-4H,(H,8,9);/q;+1

Upstream product

• 2634-33-5 1,2-benzisothiazolin-3-one 

Downstream Products

• 40991-40-0 3-butoxy-1 ,2-benzisothiazolin-3-one 
• 4299-07-4 2-butyl-1,2-benzothiazolin-3-one 
• 58249-29-9 2-benzoyl-3,4-dihydro-1,1-dioxide-1,3-2H-benzothiazin-4-one 
• 58249-30-2 2-((1,1-dioxidobenzo[d]isothiazol-3-yl)oxy)-1-phenylethan-1-one 

Relevant articles and documents

Palladium(II) benzisothiazolinate (bit) complexes with amino-, acetylamino-, heterocyclic and phosphine co-ligands. Crystal structure of [Pd(bit)2(κ2-dppe)]·2EtOH

Abstract A series of square-planar palladium(II) benzisothiazolinate (bit) of the general type [Pd(bit)2L2] have been prepared and characterized by analytical and spectroscopic methods. Two synthetic routes have been employed, namely reactions of [Pd(bit)2]·H2O with two equivalents of ligands (L = amine, amide, phosphine) or nucleophile displacement of chloride by benzisothiazolinate starting from trans-[PdCl2L2]. Both routes afford the new complexes in good yields as easily isolated, air and moisture stable, colored solids. The precursor, [Pd(bit)2]·H2O, is itself prepared in high yields upon reaction of Na[bit] with Na2[PdCl4] in methanol and the analogous platinum complex, [Pt(bit)2]·H2O, is similarly prepared from K2[PtCl4]. It is not clear if these species are mono- or dimeric, and formulation as [M2(μ-bit)4(H2O)2] with the four benzisothiazolinate spanning the metal-metal vector and possibly binding through coordination of nitrogen and oxygen is suggested. Diphosphine adducts, cis-[Pd(bit)2{κ2-Ph2P(CH2)nPPh2}] (n = 1-4) can be prepared both upon addition of the diphosphine to [Pd(bit)2]·H2O and from reactions of cis-[PdCl2{κ2-Ph2P(CH2)nPPh2}] with two equivalents of Na[bit]. A crystal structure of cis-[Pd(bit)2(κ2-dppe)] reveals that the benzisothiazolinate ligands are bonded in a monodentate fashion through nitrogen and this binding mode is proposed for all [Pd(bit)2L2] and [Pd(bit)2L] complexes. With dppb (n = 4) a second product is seen by NMR spectroscopy being proposed to be the part-substituted complex cis-[PdCl(bit)(κ2-dppb)], while with dppm (n = 1) two further products are seen spectroscopically, proposed as trans-[Pd(bit)2(κ1-dppm)2] and (more tenuously) [Pd2(bit)4(dppm)2]. The former is also prepared in good yields from reaction of [Pd(κ2-dppm)2]Cl2 with Na[bit]. These studies show that palladium benzisothiazolinate are easily accessed and show good air and moisture stability.

2-butyl-1,2-benzisothiazolin-3-one preparation method

The present invention discloses a 2-butyl-1,2-benzisothiazolin-3-one synthesis process, which comprises that (1) a starting raw material BIT reacts with an alkali to form a BIT salt; and (2) the BIT salt reacts with halogenated n-butane to obtain the target product 2-butyl-1,2-benzisothiazolin-3-one (BBIT). The present invention further discloses a separation and purification method of 2-butyl-1,2-benzisothiazolin-3-one, wherein an acid is added to a mixture containing BBIT to make the BBIT form the salt, and the obtained BBIT salt is alkalized so as to obtain the high purity BBIT. According to the present invention, the synthesis method has advantages of easily available raw materials, mild reaction condition, high yield, low cost, low environmental pollution and convenient industrial production; and with the separation and purification method, the high purity target product can be obtained, and the method can be widely used for industrial production.