58265-36-4

Basic information

• Product Name: 2-methyl-N,2-diphenylpropanamide
• CAS NO: 58265-36-4
• Molecular Formula: C₁₆H₁₇NO
• Molecular Weight: 239.3123
• Mol File: 58265-36-4.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 426.1°C at 760 mmHg
• Flash Point: 258.1°C
• Density: 1.102g/cm³
• Vapor Pressure: 1.82E-07mmHg at 25°C
• Refractive Index: 1.595
• CAS DataBase Reference: 2-methyl-N,2-diphenylpropanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-N,2-diphenylpropanamide(58265-36-4)
• EPA Substance Registry System: 2-methyl-N,2-diphenylpropanamide(58265-36-4)

Safety Data

• Hazardous Substances Data: 58265-36-4(Hazardous Substances Data)

Upstream product

• 36293-05-7 2-methyl-2-phenylpropanoyl chloride 
• 98-86-2 acetophenone 
• 201230-82-2 carbon monoxide 
• 62-53-3 aniline 
• 98-83-9 isopropenylbenzene 
• 142-04-1 aniline hydrochloride 
• 2901-13-5 ethyl 2-methyl-2-phenylpropionate 
• 98-95-3 nitrobenzene 
• 826-55-1 2-methyl-2-phenylpropionic acid 
• 2173-69-5 2-methyl-2-phenyl-propan-1-ol 
• 1678-25-7 N-phenylbenzenesulfonamide 
• 89372-28-1 1-(2-methyl-2-phenylpropanoyl)-1H-imidazole 
• 52412-43-8 5,5-dimethyl-3,4-diphenyl-4,5-dihydro-3H-[1,2,3]triazol-4-ol 
• 5682-41-7 2,3-diphenyl-2-methylpropan-3-one oxime 

Relevant articles and documents

Functionalization of α-C(sp3)?H Bonds in Amides Using Radical Translocating Arylating Groups

α-C?H arylation of N-alkylamides using 2-iodoarylsulfonyl radical translocating arylating (RTA) groups is reported. The method allows the construction of α-quaternary carbon centers in amides. Various mono- and disubstituted RTA-groups are applied to the arylation of primary, secondary, and tertiary α-C(sp3)?H-bonds. These radical transformations proceed in good to excellent yields and the cascades comprise a 1,6-hydrogen atom transfer, followed by a 1,4-aryl migration with subsequent SO2 extrusion.

Chromium-Catalyzed Activation of Acyl C-O Bonds with Magnesium for Amidation of Esters with Nitroarenes

Here, we report a chromium-catalyzed activation of acyl C-O bonds with magnesium for amidation of esters with nitroarenes. Low-cost chromium(III) chloride shows high reactivity in promoting amidation by using magnesium as reductant and chlorotrimethylsilane as additive. It provides a step-economic strategy to the synthesis of centrally important amide motifs using inexpensive and air-stable nitroarenes as amino sources.

Rhodium-Catalyzed oxidative amidation of sterically hindered aldehydes and alcohols

A rhodium-catalyzed oxidative amidation reaction has been developed with sterically hindered aldehydes and alcohols for the synthesis of amides containing a quaternary carbon at the α position. A variety of amine nucleophiles, both aliphatic and aromatic, are employed and afford the corresponding amides in good to excellent yields. Finally, mechanistic studies are performed to gain insight into both catalytic cycles.