583-08-4

Basic information

• Product Name: NICOTINOYL-GLYCINE
• Synonyms: NICOTINYLGLYCINE;NICOTINOYL-GLYCINE;NICOTINOYL-GLY-OH;NICOTINURIC ACID;NICOTINICAMIDO ACETIC ACID;N-(pyridin-3-ylcarbonyl)glycine;N-NICOTINOYLGLYCINE;N-NicotinuricAcid~99%
• CAS NO: 583-08-4
• Molecular Formula: C₈H₈N₂O₃
• Molecular Weight: 180.16
• EINECS: 209-497-0
• Product Categories: Amino Acids;Amino Acids 13C, 2H, 15N;Amino Acids & Derivatives;Aromatics;Heterocycles
• Mol File: 583-08-4.mol
• Article Data: 7

Chemical Properties

• Melting Point: 256-2580C (dec.)
• Boiling Point: 512.5 °C at 760 mmHg
• Flash Point: 263.7 °C
• Appearance: white solid
• Density: 1.343 g/cm³
• Vapor Pressure: 2.51E-11mmHg at 25°C
• Refractive Index: 1.572
• Storage Temp.: Store at 0-5°C
• Solubility: Aqueous Base (Slightly), DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
• PKA: 3.10±0.10(Predicted)
• Water Solubility: Soluble in dimethyl sulfoxide, methanol, water, and 1M NH4OH (50 mg/mL).
• CAS DataBase Reference: NICOTINOYL-GLYCINE(CAS DataBase Reference)
• NIST Chemistry Reference: NICOTINOYL-GLYCINE(583-08-4)
• EPA Substance Registry System: NICOTINOYL-GLYCINE(583-08-4)

Safety Data

• Hazard Codes: Xi
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 583-08-4(Hazardous Substances Data)

Usage

Description

NICOTINOYL-GLYCINE is a chemical compound that serves as a Niacin analog and exhibits antiproliferative properties. It is utilized for therapeutic purposes, making it a valuable component in various medical applications.

Uses

Used in Pharmaceutical Industry:
NICOTINOYL-GLYCINE is used as a therapeutic agent for its antiproliferative properties, which can be beneficial in managing the growth of certain cells and potentially treating specific conditions.
Used in Niacin Supplementation:
As a Niacin analog, NICOTINOYL-GLYCINE is used for therapeutic purposes to supplement Niacin levels in the body, which can contribute to maintaining overall health and well-being.

InChI:InChI=1/C8H8N2O3/c11-7(12)5-10-8(13)6-2-1-3-9-4-6/h1-4H,5H2,(H,10,13)(H,11,12)

Upstream product

• 4013-72-3 nicotinoyl azide 
• 56-40-6 glycine 
• 54466-74-9 N³-((ethoxycarbonyl)-methyl)nicotinamide 
• 1037820-84-0 nicotinyl-glycine-tert-butyl ester 
• 78348-28-4 nicotinic acid succinimidyl ester 
• 98-92-0 nicotinamide 
• 79-11-8 chloroacetic acid 
• 553-53-7 Nicotinic acid hydrazide 
• 59-67-6 nicotinic acid 
• 20260-53-1 pyridine-3-carbonyl chloride hydrochloride 
• 10400-19-8 3-pyridinecarbonyl chloride 

Downstream Products

• 105959-39-5 4-((4-azidophenyl)methylene)-2-(3-pyridyl)-1,3-oxazolin-5-one 
• 606142-93-2 4-(4-azido-β-methyl-cinnamylidene)-2-(3-pyridyl)-2-oxazolin-5-one 

Relevant articles and documents

New compounds: convenient preparation of nicotinoyl glycine derivatives.

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niacine or niacinamide substituted ascorbic acid derivatives and process for their preparation

PURPOSE: An ascorbic acid derivative in which niacinamide or niacine is introduced and a method for preparing the same are provided to enhance organic solvent solubility and efficiency. CONSTITUTION: A 3-O-substituted ascorbic acid derivative is denoted by chemical formula 1. A method for preparing the 3-O-substituted ascorbic acid derivative of chemical formula 1 comprises: a step of reacting 5,6-alkylidene ascorbic acid derivative with an acid derivative of chemical formula 2 in an organic solvent; and a step of deprotecting under the presence of carbodiimide of chemical formula 4. The organic solvent is amides, sulfoxides, alcohols, ethers, ketones, halogenated hydrocarbons, or fatty acid organic acid.

Synthesis and Quantitative Structure-activity Relationships Study for Arylpropenamide Derivatives as Inhibitors of Hepatitis B Virus Replication

A series of new arylpropenamide derivatives containing different aryl groups were synthesized, characterized, and evaluated for their anti-hepatitis B virus (HBV) activities. A new high accuracy QSAR model of arylpropenamide was constructed based on a more completely activities data and calculation parameter. The 2D-QSAR equations, by using DFT and multiple linear regression analysis methods, revealed that higher value of thermal energy (TE) and lower entropy (S?) increase the anti-HBV activities of the arylpropenamide molecules. Predictive 3D-QSAR models were established by SYBYL multifit molecular alignment rule. The optimum models were all statistically significant with cross-validated and conventional coefficients, indicating that they were reliable enough for activity prediction.