583057-48-1

Basic information

• Product Name: arasertaconazole
• Synonyms: arasertaconazole;(R)-Sertaconazole;1-[(2R)-2-[(7-Chlorobenzo[b]thien-3-yl)Methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-IMidazole;1-[(2R)-2-[(7-chloro-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole
• CAS NO: 583057-48-1
• Molecular Formula: C20H15Cl3N2OS
• Molecular Weight: 437.7699
• Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
• Mol File: 583057-48-1.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: arasertaconazole(CAS DataBase Reference)
• NIST Chemistry Reference: arasertaconazole(583057-48-1)
• EPA Substance Registry System: arasertaconazole(583057-48-1)

Safety Data

• Hazardous Substances Data: 583057-48-1(Hazardous Substances Data)

Usage

Description

Arasertaconazole is a derivative of sertaconazole, an imidazole antifungal agent. It is characterized by its ability to inhibit the synthesis of ergosterol, a vital component of the fungal cell wall, thereby exerting its antifungal properties.

Uses

Used in Pharmaceutical Industry:
Arasertaconazole is used as an antifungal agent for the treatment of various fungal infections. Its mechanism of action involves the inhibition of ergosterol synthesis, which is essential for the integrity and function of the fungal cell wall. This leads to the disruption of the cell wall and ultimately the death of the fungal pathogen.
Used in Antifungal Research:
In the field of antifungal research, arasertaconazole serves as a valuable compound for studying the mechanisms of antifungal action and resistance. Its unique properties and potential applications in combating drug-resistant fungal strains make it an important subject of investigation for the development of novel antifungal therapies.
Used in Drug Development:
Arasertaconazole may also be utilized in the development of new antifungal drugs. Its potential as a lead compound can be explored through medicinal chemistry approaches to optimize its pharmacological properties, such as potency, selectivity, and pharmacokinetics, ultimately leading to the creation of more effective and safer antifungal medications.

Upstream product

• 99592-32-2 sertaconazole 
• 17512-61-7 3-Bromomethyl-7-chlorobenzothiophene 
• 24155-42-8 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol 
• 142181-53-1 (7-chlorobenzo[b]thiophen-3-yl)methanol 
• 84483-28-3 2-chloro-6-iodoaniline 

Relevant articles and documents

Visible-Light-Induced Radical Carbo-Cyclization/ gem-Diborylation through Triplet Energy Transfer between a Gold Catalyst and Aryl Iodides

Geminal diboronates have attracted significant attention because of their unique structures and reactivity. However, benzofuran-, indole-, and benzothiophene-based benzylic gem-diboronates, building blocks for biologically relevant compounds, are unknown. A promising protocol using visible light and aryl iodides for constructing valuable building blocks, including benzofuran-, indole-, and benzothiophene-based benzylic gem-diboronates, via radical carbo-cyclization/gem-diborylation of alkynes with a high functional group tolerance is presented. The utility of these gem-diboronates has been demonstrated by a 10 g scale conversion, by versatile transformations, by including the synthesis of approved drug scaffolds and two approved drugs, and even by polymer synthesis. The mechanistic investigation indicates that the merging of the dinuclear gold catalyst (photoexcitation by 315-400 nm UVA light) with Na2CO3 is directly responsible for photosensitization of aryl iodides (photoexcitation by 254 nm UV light) with blue LED light (410-490 nm, λmax = 465 nm) through an energy transfer (EnT) process, followed by homolytic cleavage of the C-I bond in the aryl iodide substrates.

HPLC method for separating enantiomers of imidazole derivatives - Antifungal compounds

The aim of this study was to test separation possibility of enantiomers of nine active substances belonging to imidazole derivatives: bifonazole, butoconazole, econazole, enilconazole, fenticonazole, isoconazole, miconazole, sertaconazole and tioconazole. The study was performed using HPLC method and the CHIRALCEL OJ column (10 μm; 250 × 4.6 mm), the mobile phase flow rate of 0.8 mL/min and detection at 220 nm. Mobile phases containing hexane and the following modifiers: alcohols (2-propanol, ethanol, methanol) and diethylamine were tested. At first isocratic elution was used but some enantiomers eluted after a long retention time and their peaks were asymmetrical and too wide. Therefore, a gradient elution was developed allowing to obtain satisfactory retention times and other parameters of enentioseparation of the compounds.

METHOD FOR MANUFACTURING IMIDAZOLE COMPOUNDS AND SALTS AND PSEUDOPOLYMORPHS THEREOF

The invention relates to a method for manufacturinc sertaconazole mononitrate. The invention also relates tcsertaconazole mononitrate that is characterized by it: particle size and to sertaconazole mononitrate monohydrate.