58311-53-8

Basic information

• Product Name: (S)-3,4-Dimethyloxazolidine-2,5-dione
• Synonyms: (S)-3,4-Dimethyloxazolidine-2,5-dione;(L)-3,4-dimethyl-1,3-oxazolidine-2,5-dione;(4S)-3,4-dimethyl-1,3-oxazolidine-2,5-dione
• CAS NO: 58311-53-8
• Molecular Formula: C5H7NO3
• Molecular Weight: 129.11398
• EINECS: -0
• Mol File: 58311-53-8.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 149.5±23.0 °C(Predicted)
• Appearance: /
• Density: 1.243±0.06 g/cm3(Predicted)
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: -2.02±0.40(Predicted)
• CAS DataBase Reference: (S)-3,4-Dimethyloxazolidine-2,5-dione(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3,4-Dimethyloxazolidine-2,5-dione(58311-53-8)
• EPA Substance Registry System: (S)-3,4-Dimethyloxazolidine-2,5-dione(58311-53-8)

Safety Data

• Hazardous Substances Data: 58311-53-8(Hazardous Substances Data)

Usage

General Description

(S)-3,4-Dimethyloxazolidine-2,5-dione is a specialized chemical compound that features prominently in biochemical research and organic synthesis. As an oxazolidine derivative, it belongs to a class of organic compounds known as oxazolidines which are heterocyclic compounds with a five-membered, oxygen-containing ring. With potential applications ranging from pharmaceuticals to materials science, these types of chemicals are highly valuable to various scientific and industrial sectors. The (S)-3,4-Dimethyloxazolidine-2,5-dione compound specifically implies sterically unique, asymmetric carbon which is crucial in stereoselective reactions in fields like medicinal chemistry and drug development. As with most chemicals, proper handling and safety measures are necessary, but further research into its potential uses and benefits remains ongoing.

Upstream product

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• 75-44-5 phosgene 

Relevant articles and documents

NOVEL CONNECTED BODY AND USE THEREOF IN SPECIFIC CONJUGATION BETWEEN BIOMOLECULE AND DRUG

PROBLEM TO BE SOLVED: To provide: a method for producing a connected body; a method for using the connected body in the production of a uniform conjugate; and a method for applying the conjugate in the treatment of cancer, infectious diseases, and autoimmune diseases. SOLUTION: A novel connected body is provided that includes a 2,3-di-substituted succinic acid group or a 2-mono-substituted or 2,3-di-substituted fumaric acid or maleic acid (trans (E)- or cis (Z)-butenedioic acid) group for conjugating 2 or more compounds/cytotoxic agents per connected body with a cell-binding molecule by specifically bridge-linking to a pair of thiol on the cell-binding molecule. The connected body is exemplified by the following general formula. SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT

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The present disclosure provides methods for treating a cancer or resistant cancer with a combination of an anti-CD22 antibody-maytansine conjugate and one or more anti-cancer agents. The disclosure also encompasses methods for sensitizing a cancer with such combinations. Also provided are pharmaceutical compositions including such combinations.