58327-75-6 Usage
Description
3-AMINOTHIENO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID is an organic compound that serves as a crucial reagent in the synthesis of various pharmaceutical compounds. It is characterized by its unique chemical structure, which includes a thieno[2,3-b]pyridine core and an amino group, as well as a carboxylic acid functional group. This versatile molecule plays a significant role in the development of new drugs and therapeutic agents.
Uses
Used in Pharmaceutical Industry:
3-AMINOTHIENO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID is used as a reagent for the synthesis of (arylaminobutyl)arylpiperazines, which are compounds that act as antagonists or partial agonists of the dopamine D3 receptor. These compounds are selective for D3 receptors over the related dopamine D2 receptors, making them potential candidates for the treatment of schizophrenia.
Additionally, 3-AMINOTHIENO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID is used in the synthesis of LIMK1 inhibitors. LIMK1 (LIM domain kinase 1) is an enzyme involved in various cellular processes, including cytoskeletal organization and cell migration. Inhibition of LIMK1 has been implicated in the treatment of various diseases, such as cancer and neurodegenerative disorders, by modulating the activity of the Rho/ROCK pathway.
Check Digit Verification of cas no
The CAS Registry Mumber 58327-75-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,8,3,2 and 7 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 58327-75:
(7*5)+(6*8)+(5*3)+(4*2)+(3*7)+(2*7)+(1*5)=146
146 % 10 = 6
So 58327-75-6 is a valid CAS Registry Number.
InChI:InChI=1/C8H6N2O2S/c9-5-4-2-1-3-10-7(4)13-6(5)8(11)12/h1-3H,9H2,(H,11,12)
58327-75-6Relevant articles and documents
cGAS ANTAGONIST COMPOUNDS
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, (2017/11/06)
Disclosed are novel compounds of Formula (I) that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.
