58347-49-2

Basic information

• Product Name: 7-CHLOROPYRAZOLO[1,5-A]PYRIMIDINE
• Synonyms: 7-CHLOROPYRAZOLO[1,5-A]PYRIMIDINE;Pyrazolo[1,5-a]pyrimidine, 7-chloro-
• CAS NO: 58347-49-2
• Molecular Formula: C₆H₄ClN₃
• Molecular Weight: 153.56906
• Product Categories: Heterocycle-Pyrimidine series
• Mol File: 58347-49-2.mol
• Article Data: 9

Chemical Properties

• Melting Point: 96-98℃
• Appearance: Off-white to yellow to pink to brown/Powder
• Density: 1.51
• Refractive Index: 1.712
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -0.59±0.40(Predicted)
• CAS DataBase Reference: 7-CHLOROPYRAZOLO[1,5-A]PYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-CHLOROPYRAZOLO[1,5-A]PYRIMIDINE(58347-49-2)
• EPA Substance Registry System: 7-CHLOROPYRAZOLO[1,5-A]PYRIMIDINE(58347-49-2)

Safety Data

• Hazardous Substances Data: 58347-49-2(Hazardous Substances Data)

Usage

General Description

7-Chloropyrazolo[1,5-a]pyrimidine is a chemical compound with the molecular formula C5H3ClN4. It is a heterocyclic compound containing a pyrazole ring and a pyrimidine ring fused together. 7-Chloropyrazolo[1,5-a]pyrimidine has potential applications in the field of medicinal chemistry, as it has been shown to exhibit anticancer and antiviral activities in various studies. It is also used as a building block in the synthesis of pharmaceutical compounds. Additionally, 7-Chloropyrazolo[1,5-a]pyrimidine is a useful intermediate in organic synthesis, as it can undergo various chemical reactions to produce a wide range of derivatives with different properties and applications.

InChI:InChI=1/C6H4ClN3/c7-5-1-3-8-6-2-4-9-10(5)6/h1-4H

Upstream product

• 197367-75-2 7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-6-carboxylic acid 
• 29274-18-8 ethyl 7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-6-carboxylate 
• 57489-79-9 4H-pyrazolo[1,5-a]pyrimidin-7-one 
• 29274-23-5 4,7-dihydropyrazolo<1,5-a>pyrimidin-7-one 

Downstream Products

• 1404086-53-8 (S)-N-(1-(5-Methoxy-3-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)ethyl)pyrazolo[1,5-a]pyrimidin-7-amine 
• 877173-84-7 3-bromo-7-chloropyrazolo[1,5-a]pyrimidine 
• 137739-28-7 7-(3,5-di-t-butyl-4-hydroxyphenyl)aminopyrazolo[1,5-a]pyrimidine 

Relevant articles and documents

Selective Halogenation of Pyridines Using Designed Phosphine Reagents

Halopyridines are key building blocks for synthesizing pharmaceuticals, agrochemicals, and ligands for metal complexes, but strategies to selectively halogenate pyridine C-H precursors are lacking. We designed a set of heterocyclic phosphines that are installed at the 4-position of pyridines as phosphonium salts and then displaced with halide nucleophiles. A broad range of unactivated pyridines can be halogenated, and the method is viable for late-stage halogenation of complex pharmaceuticals. Computational studies indicate that C-halogen bond formation occurs via an SNAr pathway, and phosphine elimination is the rate-determining step. Steric interactions during C-P bond cleavage account for differences in reactivity between 2- and 3-substituted pyridines.

Imidazopyridine derivatives as PI3K inhibitors

New imidazopyridine derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Phosphoinositide 3-Kinases (PI3Ks)

PYRROLOTRIAZINONE DERIVATIVES AS PI3K INHIBITORS

New pyrrolotriazinone derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Phosphoinositide 3-Kinases (PI3Ks).