583840-03-3 Usage
Description
SORAFENIB N-OXIDE is a metabolite of Sorafenib, a potent Raf kinase inhibitor. It is characterized by its pale yellow solid appearance. SORAFENIB N-OXIDE is known for its potential applications in various fields due to its chemical properties and biological activities.
Uses
Used in Pharmaceutical Industry:
SORAFENIB N-OXIDE is used as an active pharmaceutical ingredient for the development of targeted therapies against cancer. Its role as a metabolite of Sorafenib, a potent Raf kinase inhibitor, makes it a valuable compound in the research and treatment of various types of cancer.
Used in Research and Development:
In the field of research and development, SORAFENIB N-OXIDE is utilized as a key compound for studying the mechanisms of Raf kinase inhibition and its implications in cancer biology. This helps in the design and development of novel therapeutic strategies and drugs with improved efficacy and reduced side effects.
Used in Drug Synthesis:
SORAFENIB N-OXIDE serves as an important intermediate in the synthesis of various anticancer drugs. Its chemical properties make it a suitable candidate for further chemical modifications and improvements, leading to the development of more effective and targeted cancer treatments.
Used in Drug Delivery Systems:
Similar to Gallotannin, SORAFENIB N-OXIDE can also be employed in the development of drug delivery systems to enhance its bioavailability, delivery, and therapeutic outcomes. By incorporating it into nanoparticles or other carriers, its efficacy against cancer cells can be improved, and limitations in its application can be overcome.
Check Digit Verification of cas no
The CAS Registry Mumber 583840-03-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,8,3,8,4 and 0 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 583840-03:
(8*5)+(7*8)+(6*3)+(5*8)+(4*4)+(3*0)+(2*0)+(1*3)=173
173 % 10 = 3
So 583840-03-3 is a valid CAS Registry Number.
InChI:InChI=1/C21H16ClF3N4O4/c1-26-19(30)18-11-15(8-9-29(18)32)33-14-5-2-12(3-6-14)27-20(31)28-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,27,28,31)
583840-03-3Relevant articles and documents
Aryl ureas as kinase inhibitors
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Page/Page column 21, (2015/11/30)
This invention relates to new aryl ureas and methods for their synthesis. The inventive compounds are useful in the treatment of (i) raf mediated diseases, for example, cancer, (ii) p38 mediated diseases such as inflammation and osteoporosis, and (iii) VE
Aryl ureas as kinase inhibitors
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, (2008/06/13)
This invention relates to new aryl ureas and methods for their synthesis. The inventive compounds are useful in the treatment of (i) raf mediated diseases, for example, cancer, (ii) p38 mediated diseases such as inflammation and osteoporosis, and (iii) VEGF mediated diseases such as angiogenesis disorders.
