584-82-7

Basic information

• Product Name: 2-ALLYL-4-METHOXYPHENOL
• Synonyms: 2-(2-Propenyl)-4-methoxyphenol;4-Methoxy-2-allylphenol;Nsc404069;Phenol, 2-allyl-4-methoxy-;Phenol, 4-methoxy-2-(2-propenyl)-;Wln: 1U2R bq eo1;4-methoxy-2-(prop-2-en-1-yl)phenol
• CAS NO: 584-82-7
• Molecular Formula: C₁₀H₁₂O₂
• Molecular Weight: 164.2
• Mol File: 584-82-7.mol
• Article Data: 53

Chemical Properties

• Boiling Point: 274.8°C at 760 mmHg
• Flash Point: 133.2°C
• Appearance: /
• Density: 1.05g/cm³
• Vapor Pressure: 0.00315mmHg at 25°C
• Refractive Index: 1.535
• PKA: 10.78±0.18(Predicted)
• CAS DataBase Reference: 2-ALLYL-4-METHOXYPHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ALLYL-4-METHOXYPHENOL(584-82-7)
• EPA Substance Registry System: 2-ALLYL-4-METHOXYPHENOL(584-82-7)

Safety Data

• Hazardous Substances Data: 584-82-7(Hazardous Substances Data)

Usage

Chemical compound

2-ALLYL-4-METHOXYPHENOL

Physical appearance

Pale yellow, oily liquid

Aroma

Pleasant, spicy

Found in

Essential oils such as clove oil, nutmeg, and cinnamon

Applications

Flavoring agent in food and beverages
Fragrance in perfumes and cosmetics
Topical analgesic and antiseptic in medicine

Properties

Antioxidant
Anti-inflammatory
Antimicrobial

Use in

Pharmaceuticals
Personal care products

Other uses

Synthesis of other chemicals
Fumigant to control pests in agriculture

Caution

Can cause skin and respiratory irritations in high concentrations

InChI:InChI=1/C10H12O2/c1-3-4-8-7-9(12-2)5-6-10(8)11/h3,5-7,11H,1,4H2,2H3

Upstream product

• 101-84-8 diphenylether 
• 13391-35-0 allyl (4-methoxyphenyl) ether 
• 111-90-0 ethoxyethoxyethanol 
• 121-69-7 N,N-dimethyl-aniline 
• 4873-09-0 allyl tosylate 
• 150-76-5 4-methoxy-phenol 
• 959697-71-3 2-allyl-4-methoxy-1-prop-2-ynyloxy-benzene 
• 37592-19-1 3-allyloxyanisole 
• 1746-13-0 allyl phenyl ether 
• 106-95-6 allyl bromide 
• 123-31-9 hydroquinone 

Downstream Products

• 205433-71-2 2-allyl-4,4-dimethoxy-2,5-cyclohexadienone 
• 13391-31-6 4-methoxy-2-propylphenol 
• 13391-27-0 5-methoxy-2-methylbenzofuran 
• 272125-02-7 2-(7-chloro-4,4,5,5,6,6,7,7-octafluoro-2-iodo-heptyl)-4-methoxy-phenol 
• 272125-03-8 2-(9-chloro-4,4,5,5,6,6,7,7,8,8,9,9-dodecafluoro-2-iodo-nonyl)-4-methoxy-phenol 
• 3731-95-1 2-allyl-1,4-benzoquinone 
• 223139-83-1 2-(5-chloro-4,4,5,5-tetrafluoro-pentyl)-benzene-1,4-diol 
• 272125-07-2 2-(5-chloro-4,4,5,5-tetrafluoro-pentyl)-4-methoxy-phenol 
• 272125-08-3 2-(7-chloro-4,4,5,5,6,6,7,7-octafluoro-heptyl)-4-methoxy-phenol 
• 223139-89-7 2-(7-chloro-4,4,5,5,6,6,7,7-octafluoro-heptyl)-benzene-1,4-diol 
• 223139-97-7 2-(9-chloro-4,4,5,5,6,6,7,7,8,8,9,9-dodecafluoro-nonyl)-benzene-1,4-diol 
• 272125-09-4 2-(9-chloro-4,4,5,5,6,6,7,7,8,8,9,9-dodecafluoro-nonyl)-4-methoxy-phenol 
• 272125-11-8 4-methoxy-2-(4,4,5,5,6,6,7,7,8,8,9,9,9-tridecafluoro-nonyl)-phenol 
• 256342-49-1 2-(4,4,5,5,6,6,7,7,8,8,9,9,9-tridecafluoro-nonyl)-benzene-1,4-diol 

Relevant articles and documents

Allylphenols as a new class of human 15-lipoxygenase-1 inhibitors

In this study, a series of mono- and diallylphenol derivative were designed, synthesized, and evaluated as potential human 15-lipoxygenase-1 (15-hLOX-1) inhibitors. Radical scavenging potency of the synthetic allylphenol derivatives was assessed and the results were in accordance with lipoxygenase (LOX) inhibition potency. It was found that the electronic natures of allyl moiety and para substituents play the main role in radical scavenging activity and subsequently LOX inhibition potency of the synthetic inhibitors. Among the synthetic compounds, 2,6-diallyl-4-(hexyloxy)phenol (42) and 2,6-diallyl-4-aminophenol (47) showed the best results for LOX inhibition (IC50 = 0.88 and 0.80 μM, respectively).

TRICYCLIC FURAN-SUBSTITUTED PIPERIDINEDIONE COMPOUND

Disclosed are a series of tricyclic furan-substituted piperidinedione compounds and an application thereof in preparing a drug for treating a disease related to CRBN protein. In particular, disclosed is a derivative compound represented by formula (I) or a pharmaceutically acceptable salt thereof.

Novel potent vasodilating agents: Evaluation of the activity and potency of LINS01005 and derivatives in rat aorta

Cardiovascular diseases (CVDs) present high prevalence rates in the current world. It is estimated that approximately one-third of the global deaths are related to CVDs, and thus there is still a need for novel drugs to treat these disorders. We serendipitously discovered that LINS01005 (5a) is a potent vasodilating agent in rat aorta, and therefore a set of analogues were evaluated for the vasodilating potency in Wistar and SHR rat thoracic aorta precontracted with norepinephrine, with endothelium intact (E+) or denuded (E–) aortic rings. Compounds 5a and 5b were the most potent, showing submicromolar potency for endothelium intact vessels (EC50 853 and 941 nM, respectively) and micromolar values for E– vessels (EC50 2.4 and 7.1 μM, respectively). These compounds were indeed significantly more potent vasodilating agents in SHR-derived aortic rings (p 50 2.4 nM (E+) 9.0 nM (E–)] and 5b [EC50 20 nM (E+) 2.1 μM (E–)]. SAR analysis though PCA and HCA were performed, suggesting that N-phenylpiperazine is essential to the activity, while increasing volume in the substituted aromatic moiety is detrimental to the potency. This is the first report of the vasodilating properties of such compounds, and studies regarding the mechanism of action are in progress in our group.