5840-15-3

Basic information

• Product Name: 3-anilinopropane-1,2-diol
• Synonyms: 3-anilinopropane-1,2-diol;3-phenylamino-1,2-propanediol;(S)-3-(PHENYLAMINO)PROPANE-1,2-DIOL;3-(N-PHENYLAMINO)-1,2-PROPANEDIOL;(R)-3-(PHENYLAMINO)PROPANE-1,2-DIOL;N-(2,3-Dihydroxypropyl)aniline;1,2-Propanediol, 3-phenylamino-;Einecs 227-428-2
• CAS NO: 5840-15-3
• Molecular Formula: C₉H₁₃NO₂
• Molecular Weight: 167.20502
• EINECS: 227-428-2
• Mol File: 5840-15-3.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 384.6°Cat760mmHg
• Flash Point: 194.5°C
• Appearance: /
• Density: 1.217g/cm³
• Vapor Pressure: 1.33E-06mmHg at 25°C
• Refractive Index: 1.618
• CAS DataBase Reference: 3-anilinopropane-1,2-diol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-anilinopropane-1,2-diol(5840-15-3)
• EPA Substance Registry System: 3-anilinopropane-1,2-diol(5840-15-3)

Safety Data

• Hazardous Substances Data: 5840-15-3(Hazardous Substances Data)

Usage

Description

3-anilinopropane-1,2-diol, also known as ChEBI, is a glycol derivative of glycerol where one of the hydroxy groups is substituted by an anilino group. 3-anilinopropane-1,2-diol exhibits unique chemical properties due to the presence of the anilino group, which can potentially lead to various applications in different industries.

Uses

Used in Pharmaceutical Industry:
3-anilinopropane-1,2-diol is used as an active pharmaceutical ingredient for its potential therapeutic effects. The presence of the anilino group may provide specific interactions with biological targets, making it a candidate for the development of new drugs.
Used in Chemical Synthesis:
In the chemical industry, 3-anilinopropane-1,2-diol can be used as a building block or intermediate in the synthesis of more complex organic compounds. The anilino group can be further modified or used as a starting point for the creation of various chemical products.
Used in Material Science:
3-anilinopropane-1,2-diol may find applications in the development of new materials due to its unique chemical structure. The anilino group could potentially be utilized to create novel polymers or other materials with specific properties, such as improved conductivity or enhanced mechanical strength.
Used in Research and Development:
As a glycol derivative with a unique structure, 3-anilinopropane-1,2-diol can be employed in research and development for studying its properties and potential applications. This may include investigating its interactions with biological systems, its use in drug discovery, or its role in the synthesis of new compounds.

InChI:InChI=1/C9H13NO2/c11-7-9(12)6-10-8-4-2-1-3-5-8/h1-5,9-12H,6-7H2

Upstream product

• 556-52-5 oxiranyl-methanol 
• 62-53-3 aniline 
• 96-24-2 3-monochloro-1,2-propanediol 
• 142-04-1 aniline hydrochloride 
• 931-40-8 4-hydroxymethyl-1,3-dioxolan-2-one 
• 100994-75-0 4-[(phenylamino)methyl]-1,3-dioxolan-2-one 
• 56-81-5 glycerol 
• 616-38-6 carbonic acid dimethyl ester 
• 110493-28-2 1-(N-phenylamino)-3-ethoxy-2-propanol 
• 103-70-8 Formanilid 
• 591-50-4 iodobenzene 
• 616-30-8 3-Amino-1,2-propanediol 

Downstream Products

• 91-22-5 quinoline 
• 83-34-1 3-Methylindole 
• 34631-64-6 (3-phenyl-oxazolidin-5-yl)-methanol 
• 34631-57-7 (2-methyl-3-phenyl-oxazolidin-5-yl)-methanol 
• 29218-21-1 5-(hydroxymethyl)-3-phenyl-2-oxooxazolidine 
• 29306-25-0 5-carbamoyloxymethyl-3-phenyl-oxazolidin-2-one 
• 67959-75-5 5-hydroxy-3-phenyl-1,3-oxazinan-2-one 
• 83585-59-5 (1,4,7,10,13,16-Hexaoxa-cyclooctadec-2-ylmethyl)-phenyl-amine 
• 95416-26-5 1,2-dioleyl ester of 3-(N-phenylamino)-1,2-propanediol 
• 102390-02-3 1-oleyl ester of 3-(N-phenylamino)-1,2-propanediol 
• 151191-96-7 N-(2,3-dihydroxypropyl)oleanilide 
• 83585-51-7 (1,4,7,10,13-Pentaoxa-cyclopentadec-2-ylmethyl)-phenyl-amine 

Relevant articles and documents

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A Multicomponent Approach to Oxazolidinone Synthesis Catalyzed by Rare-Earth Metal Amides

Three-component reaction of epoxides, amines, and dimethyl carbonate catalyzed by rare-earth metal amides has been developed to synthesize oxazolidinones. 47 examples of 3,5-disubstituted oxazolidinones were prepared in 13–97 % yields. This is a simple and most practical method which employs easily available substrates and catalysts, and is applicable to a wide range of aromatic and aliphatic amines, as well as mono-substituted epoxides. Scope of disubstituted epoxides is rather limited, which requires further study. Preliminary mechanistic study reveals two possible reaction pathways through intermediates of β-amino alcohols or amides.

DISUBSTITUTED OXAZOLIDIN-2-ONES 5-HYDROXYTRYPTAMINE RECEPTOR 2B ACTIVITY MODULATORS

Pharmaceutical compositions of the invention comprise disubstituted oxazolidin-2-ones derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of 5-hydroxytryptamine receptor 2b activity.

Copper-catalyzed aryl amination in aqueous media with 2- dimethylaminoethanol ligand

Copper-catalyzed amination of aryl bromides and iodides under mild conditions has been developed with 2-dimethylaminoethanol as ligand and water as solvent. A variety of hydrophilic and hydrophobic aryl halide substrates have been aminated in good yield with a variety of amino acids, amino alcohols and peptides. This method has successfully N-arylated some hydrophilic amino compounds not available by other methods.