5845-68-1Relevant articles and documents
PHENACYL ESTERS OF AMINO ACIDS AND PEPTIDES
Popova, O. Yu.,Yung, R.,Mitin, Yu. V.
, p. 1499 - 1502 (2007/10/02)
The behavior of phenacyl esters under the conditions of peptide synthesis was investigated.The cleavage of phenacyl esters in reaction with primary amines, as a result of which the carboxyl group is liberated, was discovered.In the presence of lower alcohols the phenacyl esters can undergo transesterification.The phenacyl group is removed by treatment with zinc dust in mixtures of acetic acid with dimethylformamide or trifluoroethanol.