58583-07-6Relevant articles and documents
MLN8054 and Alisertib (MLN8237): Discovery of Selective Oral Aurora A Inhibitors
Sells, Todd B.,Chau, Ryan,Ecsedy, Jeffrey A.,Gershman, Rachel E.,Hoar, Kara,Huck, Jessica,Janowick, David A.,Kadambi, Vivek J.,Leroy, Patrick J.,Stirling, Matthew,Stroud, Stephen G.,Vos, Tricia J.,Weatherhead, Gabriel S.,Wysong, Deborah R.,Zhang, Mengkun,Balani, Suresh K.,Bolen, Joseph B.,Manfredi, Mark G.,Claiborne, Christopher F.
, p. 630 - 634 (2015/06/30)
The Aurora kinases are essential for cell mitosis, and the dysregulation of Aurora A and B have been linked to the etiology of human cancers. Investigational agents MLN8054 (8) and alisertib (MLN8237, 10) have been identified as high affinity, selective,
N-oxides of 5-oxo-1-phenyl-2-benzazepines
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, (2008/06/13)
Compounds of the formula STR1 wherein X and Y are selected from the group consisting of hydrogen, halogen and trifluoromethyl, are disclosed. The compounds are useful as intermediates in the production of 2-benzazepines, compounds of pharmacological activ
Intermediates in the production of 2-benzazepines
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, (2008/06/13)
Compounds of the formula STR1 wherein X and Y are selected from the group consisting of hydrogen, halogen and trifluoromethyl, are disclosed. The compounds are useful as intermediates in the production of 2-benzazepines, compounds of pharmacological activ