58589-70-1Relevant articles and documents
Structures, Phase Behavior, and Fluorescent Properties of 3-Phenyl-1-(pyridin-2-yl)-1 H-pyrazol-5-amine and Its ZnCl2 Complex
Hiscock, Lana K.,Joekar, Delara,Balonova, Barbora,Tomas Piqueras, Marta,Schroeder, Zachary W.,Jarvis, Victoria,Maly, Kenneth E.,Blight, Barry A.,Dawe, Louise N.
, p. 16317 - 16321 (2019)
The synthesis of the asymmetric ligand 3-phenyl-1-(pyridin-2-yl)-1H-pyrazol-5-amine (L1) and its single-crystal X-ray structure are reported. L1 displays crystallographic symmetry (orthorhombic, Pccn) higher than its molecular symmetry (point group C1) and also displays supercooling, with a difference in the melting and solidification points of over 100 °C. Upon complexation with ZnCl2, L1 engages in both primary cation and secondary anion coordination via hydrogen bonding, and the complex exhibits a room-to-low-temperature single crystal-to-crystal phase transition. The ZnCl2 complex becomes a birefringent fluid mixed with crystalline domains at high temperatures, as detected by polarized optical microscopy. Examination of the photoluminescence properties showed that the emission intensity increased and a pronounced bathochromic shift was observed in the emission maximum upon going from solution to the solid state, for both the ligand and complex, consistent with aggregation-induced emission behavior.
Heterocycles of Biological Importance. Part 2. Novel Synthesis and Pharmacological Evaluation of 5-Amino-3-alkyl-1-(2-pyridyl)pyrazoles and 5-Amino-3-phenyl-1-(2-pyridyl)pyrazole from Allenic or Acetylenic Nitriles and 2-Hydrazinopyridine
Fomum, Tanee Z.,Ifeadike, Ngozi P.
, p. 1611 - 1614 (2007/10/02)
2-Hydrazinopyridine reacts with allenic and acetylenic nitriles to give 5-amino-3-alkyl-1-(2-pyridyl)pyrazoles 6 in excellent yields.One of these compounds, 6e has been shown to possess anticonvulsant and anti-electroshock properties.Phenyl propynenitrile
