5875-50-3

Basic information

• Product Name: phosphopantothenic acid
• Synonyms: phosphopantothenic acid;(R)-4'-phosphopantothenic acid
• CAS NO: 5875-50-3
• Molecular Formula: C₉H₁₈NO₈P
• Molecular Weight: 299.21
• Mol File: 5875-50-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.553g/cm³
• Refractive Index: 1.555
• CAS DataBase Reference: phosphopantothenic acid(CAS DataBase Reference)
• NIST Chemistry Reference: phosphopantothenic acid(5875-50-3)
• EPA Substance Registry System: phosphopantothenic acid(5875-50-3)

Safety Data

• Hazardous Substances Data: 5875-50-3(Hazardous Substances Data)

Usage

Description

Phosphopantothenic acid, also known as the 4-phosphate derivative of (R)-pantothenic acid, is an amidoalkyl phosphate. It plays a crucial role in various biological processes and has potential applications in different industries due to its unique chemical properties.

Uses

Used in Pharmaceutical Industry:
Phosphopantothenic acid is used as an active pharmaceutical ingredient for its potential role in the synthesis of coenzyme A (CoA), which is essential for various metabolic pathways in the human body. It contributes to the production of energy and the synthesis of fatty acids, cholesterol, and acetate.
Used in Cosmetic Industry:
In the cosmetic industry, phosphopantothenic acid is used as a skin conditioning agent. It helps improve skin elasticity and hydration, promoting a healthier and more youthful appearance.
Used in Food Industry:
Phosphopantothenic acid is utilized as a nutrient and additive in the food industry. It is an essential component of CoA, which is involved in the metabolism of carbohydrates, fats, and proteins, making it a valuable addition to dietary supplements and fortified foods.
Used in Research and Development:
Phosphopantothenic acid is also used in research and development for its potential applications in the study of cellular metabolism, enzyme function, and the development of new drugs targeting various diseases.

InChI:InChI=1/C9H18NO8P/c1-9(2,4-11)6(12)7(13)10-3-5(8(14)15)19(16,17)18/h5-6,11-12H,3-4H2,1-2H3,(H,10,13)(H,14,15)(H2,16,17,18)

Upstream product

• 10527-68-1 ethyl D-pantothenate 
• 2212-88-6 2-Cyanoethyl phosphate 
• 79-83-4 pantothenic acid 
• 25614-48-6 3-[4-(bis-benzyloxy-phosphoryloxy)-2(R)-hydroxy-3,3-dimethyl-butyrylamino]propionate 
• 50692-78-9 methyl 3-[[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]propanoate 

Relevant articles and documents

INVESTIGATIONS IN THE FIELD OF ACYL GROUP CARRIERS. XVI. HYDROLYTIC STABILITY AND ENZYMATIC DEPHOSPHORYLATION OF D-PANTOTHENIC ACID 4'-PHOSPHATE

Samples of D-pantothenic acid 4'-phosphate (I) have been investigated by IR spectroscopy in dimethyl sulfoxide and deuterated water and in the form of a thin film without a solvent.The vibrations of the carbonyl and amide groupings in (I) as compared with pantothenic acid (II) are found at higher frequencies in all media, which indicate the greater strength of these bonds.It is assumed that the resistance of (I) to hydrolysis as compared with (II) is due to the inclusion of the phosphate in a macrocycle by the formation of hydrogen bonds between the phosphate, hydroxy, amide, and carboxy groups of the molecule.The complete dephosphorylation of (I) has been achieved in concentrations of 0.0075 and 0.005 mM with the aid of a dialyzed preparation of orthophosphate monoester phosphohydrolase (E.C. 3.1.3.1).

Identification of Specific and Nonspecific Inhibitors of Bacillus anthracis Type III Pantothenate Kinase (PanK)

Antibiotics with novel mechanisms of action are desperately needed to combat the increasing rates of multidrug-resistant infections. Bacterial pantothenate kinase (PanK) has emerged as a target of interest to cut off the biosynthesis of coenzyme A. Herein we report the results of an in vitro high-throughput screen of over 10 000 small molecules against Bacillus anthracis PanK, as well as a follow-up screen of hits against PanK isolated from Pseudomonas aeruginosa and Burkholderia cenocepacia. Nine hits are structurally categorized and analyzed to set the stage for future drug development.