58759-26-5Relevant articles and documents
Metal free [4+1] and [5+1] annulation reactions to prepare heterocycles using DMF and its derivatives as one-carbon source
Liu, Lingfeng,Qiao, Chunhua,Shen, Bei,Xu, Yiwen
, (2020/04/01)
1,2,4-Triazolo[3,4-a]pyridines and related heterocycles and substituted triazines were commonly discovered scaffolds in a variety of pharmaceutical and agrochemical agents. Herein, we report a highly efficient and practical method using DMF and its derivative for the [4+1] and [5+1] annulation reactions to prepare these heterocycles. This metal free reaction takes advantages of shelf stable DMF as solvent and carbon donor, imidazole chloride as a catalyst, the mild reaction condition tolerates a broad substrate range and substitutes. The prepared 3-unsubstituted 1,2,4-triazolo[3,4-a]pyridine and derivatives allow further introduction of a variety of functional group1 at 3-position.
Diuretics on the basis of N substituted 2,4 diamino s triazines by cyclisation of biguanides
Kreutzberger
, p. 1860 - 1862 (2007/10/04)
The structural class of 2,4 diamino s triazines (5) functioning as diuretics has become accessible by a novel preparatory procedure. The new synthesis is based on the aminomethinylating principle of s triazine (1), under the action of which biguanides (2) are cyclized to 5 passing through the intermediary states 3 and 4.
