58801-34-6 Usage
Description
ETH 1001, also known as Calcium ionophore I, is a Ca2+-selective ionophore specifically designed for biological membranes. It is primarily utilized in microelectrodes for the accurate determination of intracellular Ca2+ activities and the monitoring of slowly changing Ca2+ levels within cells. ETH 1001 plays a crucial role in various research and diagnostic applications, particularly in the study of cellular processes involving calcium ions.
Uses
Used in Research and Diagnostics:
ETH 1001 is used as a research and diagnostic tool for studying cellular processes that involve calcium ions. Its ability to selectively transport Ca2+ across biological membranes makes it an essential component in microelectrodes, allowing for precise measurement of intracellular Ca2+ activities and monitoring of slowly changing Ca2+ levels.
Used in Cell Signaling Studies:
In the field of cell signaling, ETH 1001 is employed as a valuable tool for investigating the role of calcium ions in various signaling pathways. By facilitating the transport of Ca2+ across cell membranes, it helps researchers understand the complex interactions between calcium ions and other cellular components, leading to a better understanding of cellular communication and regulation.
Used in Pharmaceutical Development:
ETH 1001 is also used in the development of pharmaceuticals targeting calcium-related conditions. Its ability to modulate intracellular Ca2+ levels can be harnessed to develop drugs that influence cellular processes, potentially leading to novel treatments for a range of diseases and disorders associated with calcium dysregulation.
Used in Biotechnology:
In the biotechnology industry, ETH 1001 is utilized as a key component in the development of advanced biosensors and diagnostic devices. Its Ca2+-selective properties enable the creation of highly sensitive and specific sensors for detecting and monitoring calcium ion levels in various applications, including environmental monitoring, food safety, and medical diagnostics.
Used in Education and Training:
ETH 1001 is also used in educational and training settings to provide hands-on experience for students and researchers in the field of cell biology, biochemistry, and pharmacology. By working with this compound, individuals can gain a deeper understanding of the role of calcium ions in cellular processes and develop the skills necessary for conducting research in these areas.
Purification Methods
This is a neutral Ca selectophore. It can be purified by thick layer (2mm) chromatography (Kieselgel F245) and eluted with Me2CO/CHCl3 (2:1). [Ammann et al. Helv Chim Acta 56 1780 1973, Simon & Carafoli Methods Enzymol 56 439 1977.]
references
dagostino m, lee co. neutral carrier na+- and ca2+-selective microelectrodes for intracellular application. biophys j. 1982 dec;40(3):199-207.caroni p, gazzotti p, vuilleumier p, et al. ca2+ transport mediated by a synthetic neutral ca2+ -ionophore in biological membranes. biochim biophys acta. 1977 nov 1;470(3):437-45.hinds tr, vincenzi ff. the effect of eth 1001 on ion fluxes across red blood cell membranes. cell calcium. 1985 jun;6(3):265-79.lücke a, lehmenkühler a, speckmann ej. the influence of the convulsant pentylenetetrazol on ca2+-selective microelectrodes (neutral carrier eth 1001). j neurosci methods. 1989 aug;29(2):139-42.lee mh, yoo cl, lee js, et al. tweezer-type neutral carrier-based calcium-selective membrane electrode with drastically reduced anionic interference. anal chem. 2002 jun 1;74(11):2603-7.
Check Digit Verification of cas no
The CAS Registry Mumber 58801-34-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,8,8,0 and 1 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 58801-34:
(7*5)+(6*8)+(5*8)+(4*0)+(3*1)+(2*3)+(1*4)=136
136 % 10 = 6
So 58801-34-6 is a valid CAS Registry Number.
InChI:InChI=1/C38H71N2O8/c1-6-45-37(43)25-21-17-13-9-8-11-15-19-23-28-40(29-24-20-16-12-10-14-18-22-26-38(44)46-7-2)30-27-39(5)35(41)31-47-33(3)34(4)48-32-36(40)42/h33-34H,6-32H2,1-5H3/q+1
