58816-66-3

Basic information

• Product Name: H-4-NITRO-PHE-OET HCL
• Synonyms: P-NITRO-L-PHENYLALANINE ETHYL ESTER HYDROCHLORIDE;ETHYL (S)-2-AMINO-3-(4-NITROPHENYL)PROPANOIATE;H-PHE(4-NO2)-OET HCL;H-4-NITRO-PHE-OET HCL;4-NITRO-L-PHENYLALANINE ETHYL ESTER HYDROCHLORIDE;ethyl 4-nitro-3-phenyl-L-alaninate monohydrochloride;3-(4-NITRO-PHENYL)-L-ALANINE ETHYL ESTER HCL;p-Nitrophenylalanine ethyl ester hydrochloride
• CAS NO: 58816-66-3
• Molecular Formula: C₁₁H₁₄N₂O₄*ClH
• Molecular Weight: 274.7
• EINECS: 261-455-0
• Product Categories: Phenylalanine [Phe, F]
• Mol File: 58816-66-3.mol
• Article Data: 4

Chemical Properties

• Melting Point: 177-180 °C
• Boiling Point: 372.1 °C at 760 mmHg
• Flash Point: 178.9 °C
• Appearance: /
• Density: 1.246 g/cm³
• Vapor Pressure: 9.83E-06mmHg at 25°C
• Refractive Index: 1.556
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: H-4-NITRO-PHE-OET HCL(CAS DataBase Reference)
• NIST Chemistry Reference: H-4-NITRO-PHE-OET HCL(58816-66-3)
• EPA Substance Registry System: H-4-NITRO-PHE-OET HCL(58816-66-3)

Safety Data

• Hazardous Substances Data: 58816-66-3(Hazardous Substances Data)

Usage

General Description

H-4-NITRO-PHE-OET HCL, also known as 4-nitrophenyl ethyl ether hydrochloride, is a chemical compound used in the synthesis of pharmaceuticals, agrochemicals, and organic compounds. It is a nitrophenyl ether derivative, which contains a nitro group and an ether functional group. H-4-NITRO-PHE-OET HCL is used as a reagent in organic synthesis, particularly in the formation of carbon-carbon and carbon-oxygen bonds. It is also used as a building block in the preparation of various biologically active compounds and in the development of new medicinal products. Additionally, it is utilized as a chemical intermediate in the production of dyes, polymers, and other organic materials.

InChI:InChI=1/C11H14N2O4/c1-2-17-11(14)10(12)7-8-3-5-9(6-4-8)13(15)16/h3-6,10H,2,7,12H2,1H3/t10-/m0/s1

Upstream product

• 64-17-5 ethanol 
• 949-99-5 4-nitro-3-phenyl-L-alanine 

Downstream Products

• 36097-40-2 (S)-ethyl 2-acetamido-3-(4-nitrophenyl)propanoate 
• 17451-67-1 N-phthalimido-4-nitro-L-phenylalanine ethyl ester 
• 34276-53-4 ethyl (S)-2-amino-3-(4-nitrophenyl)propionate 
• 189744-28-3 N-(tert-butyloxycarbonyl)-4-(bis(2-chloroethyl)amino)-L-phenylalanine ethyl ester 
• 189744-27-2 N-boc-L-3-(4-bis(hydroxyethyl)aminophenyl)alanine ethyl ester 
• 67630-01-7 (S)-3-(4-aminophenyl)-2-tert-butoxycarbonylamino-propionic acid ethyl ester 
• 644995-08-4 3-(4-nitrophenyl)-2(S)-(3-oxospiro[3.5]non-1-en-1-ylamino)propionic acid ethyl ester 
• 1031337-85-5 ethyl N-(4,4-dimethyl-3-oxocyclobut-1-en-1-yl)-4-nitro-L-phenylalaninate 
• 263274-93-7 S-ethyl-3-(4-nitrophenyl)-2-[(4,6-dimethoxy-1,3,5-triazin-2-yl)amino]propionate 
• 67630-00-6 N-(tert-butyloxycarbonyl)-4-nitro-L-phenylalanine ethyl ester 

Relevant articles and documents

A PROCESS FOR THE SYNTHESIS OF MELPHALAN

The invention relates to a process for the preparation of Melphalan (4-[bis(2-5 chloroethyl)amino]-L-phenylalanine of formula (I) said process comprising the reaction of a 4-amino-L-phenylalanine protected at the carboxy and amino aminoacidic groups with an agent able to convert the aromatic amino group into a group of formula: -N(CH2CH2OS(O)nO-)2, wherein n is 1 or 2 followed by conversion of the –-N(CH2CH2OS(O)nO-)2 group into a -N(CH2CH2Cl)2 group. The invention also provides novel intermediates useful for the preparation of Melphalan.

VLA-4 ANTAGONISTS

Substituted N-[N-(sulphonylphenyl)sulfonyl-prolyl]-phenylalanine derivatives of the present invention are antagonists of the VLA-4 integrin and are useful in the treatment, prevention and suppression of diseases mediated by VLA-4-binding and cell adhesion and activation. Moreover, the compounds of the present invention demonstrate significant receptor occupancy of VLA-4 bearing cells after oral administration and are suitable for once-, twice-, or thrice-a-day oral administration. This invention also relates to compositions containing such compounds and methods of treatment using such compounds.