58819-77-5

Basic information

• Product Name: 6-BROMO-2-METHOXY-3-NITRO-PYRIDINE
• Synonyms: 6-BROMO-2-METHOXY-3-NITRO-PYRIDINE;2-Methoxy-3-Nitro-6-Bromopyridine;Pyridine, 6-broMo-2-Methoxy-3-nitro-
• CAS NO: 58819-77-5
• Molecular Formula: C₆H₅BrN₂O₃
• Molecular Weight: 233.02
• Product Categories: Pyridine
• Mol File: 58819-77-5.mol
• Article Data: 4

Chemical Properties

• Melting Point: 92 °C(Solv: benzene (71-43-2))
• Boiling Point: 281.982 °C at 760 mmHg
• Flash Point: 124.339 °C
• Appearance: /
• Density: 1.73 g/cm³
• Vapor Pressure: 0.006mmHg at 25°C
• Refractive Index: 1.587
• Storage Temp.: 2-8°C
• PKA: -5.08±0.10(Predicted)
• CAS DataBase Reference: 6-BROMO-2-METHOXY-3-NITRO-PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-BROMO-2-METHOXY-3-NITRO-PYRIDINE(58819-77-5)
• EPA Substance Registry System: 6-BROMO-2-METHOXY-3-NITRO-PYRIDINE(58819-77-5)

Safety Data

• Hazard Codes: Xi:
• Statements: 20/21/22
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 58819-77-5(Hazardous Substances Data)

Usage

General Description

6-Bromo-2-methoxy-3-nitro-pyridine is a chemical compound with the molecular formula C6H5BrN2O3. It can also be referred to by its IUPAC name, 6-bromo-2-methoxy-3-nitropyridine. 6-BROMO-2-METHOXY-3-NITRO-PYRIDINE is largely used in the research and development phases of various chemical and pharmaceutical industries and it is typically sold as a reactant. Its structure showcases multiple funcational groups, including a bromine atom, a methoxy group, and a nitro group. The specific arrangement of these groups on the pyridine ring contributes to the compound's chemical reactivity and behavior. The physical and chemical properties, as well as the safety, handling, and storage recommendations, can be found in the material safety data sheet provided by the chemical supplier. Detecting the potential hazards, understanding the appropriate handling techniques, and knowing how to respond in case of accident are essential to safely work with this chemical.

InChI:InChI=1/C6H5BrN2O3/c1-12-6-5(9(10)11)2-4(7)3-8-6/h2-3H,1H3

Upstream product

• 55304-80-8 2,6-dibromo-3-nitropyridine 
• 124-41-4 sodium methylate 

Downstream Products

• 954368-96-8 6-(2-(benzyl-propyl-amino)-ethoxy)-2-methoxy-pyridin-3-ylamine 
• 954368-92-4 6-(1-benzyl-pyrrolidin-3-yloxy)-2-methoxy-pyridin-3-ylamine 
• 954368-95-7 benzyl-[2-(6-methoxy-5-nitro-pyridin-2-yloxy)-ethyl]-propyl-amine 
• 954368-91-3 6-(1-benzyl-pyrrolidin-3-yloxy)-2-methoxy-3-nitro-pyridine 

Relevant articles and documents

TRIAZINE DERIVATIVE HAVING EGFR INHIBITORY ACTIVITY, PREPARATION METHOD THEREFOR AND USE THEREOF

Disclosed are a triazine derivative having EGFR inhibitory activity, a preparation method therefor and use thereof. In particular, disclosed are an EGFR inhibitor having a structure of formula (I), a preparation method therefor, a pharmaceutical composition containing same, use thereof for preparing the EGFR inhibitor, and use thereof in preparing medicaments for treating and/or preventing cancers, tumors or metastatic diseases at least partially related to insertion, deletion or other mutation of EGFR exon 20, and in particular use thereof in preparing medicaments for treating and/or preventing hyperproliferative diseases and diseases inducing cell death disorders. The definition of each substituent of formula (I) is the same as that in the description.

Epidermal growth factor receptor inhibitor and preparation and application thereof

The invention relates to 2-aminopyrimidine derivatives with a structure of a formula (I), a pharmaceutical composition containing the compounds of the formula (I) and application of the compounds in preparation of drugs for prevention or treatment of epidermal growth factor receptor (EGFR) kinase-related diseases, especially application of the compounds in prevention or treatment of cancers related to epidermal growth factor receptor kinase. Substituents in the formula (I) are the same as defined in the description.